One cell at a time, researchers create a blueprint of liver cells in health and disease

One cell at a time, researchers create a blueprint of liver cells in health and disease

Publication date: Aug 11, 2019

In a new study led by the University of Michigan, researchers have now created a high-resolution picture of the cells at work inside a key hub of metabolism — the liver — and how individual cell types are reprogrammed in disease.

“That was one question we really wanted to address with this study: Can we have a high-definition picture of each cell type in the liver, what signaling molecules are being released by each of these different cell types and what they are capable of responding to?”

Lin and his colleagues applied this new research tool to obtain a gene expression profile for individual liver cells.

“We wanted to decode what exactly is going on for each cell type during disease,” said Lin, who is also a professor of cell and developmental biology at the U-M Medical School.

Using a mouse model of NASH, the researchers found that the abundance of cells within the liver changed with disease, but so did the properties of each cell type.

Study authors also include: Henry Kuang, Sahar Ansari, Tongyu Liu, Jianke Gong, Xuyun Zhao, Yewei Ji, Liang Guo, Linkang Zhou, Zhimin Chen, Meng Ting Chung, Katsuo Kurabayashi, Judy Opp, Robert Lyons, Ling Qi, X. Z. Shawn Xu, Siming Li, Jun Li and Carey Lumeng, all of U-M; Chuan Li and Beiyan Zhou, University of Connecticut; Paola Leon-Mimila, Adriana Huertas-Vazquez and Aldons Lusis, University of California, Los Angeles; Francisco Campos-PcE9rez, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico; Hugo Villamil-RamcEDrez and Samuel Canizales-Quinteros, Unidad de GencF3mica de Poblaciones Aplicada a la Salud, Mexico; and Shuai Wang and Yonghao Yu, University of Texas Southwestern Medical Center.

Concepts Keywords
Blood Hepatocellular carcinoma
California Hepatic stellate cell
Cell Signaling Histopathology
Cirrhosis Macrophages
Cohort Fatty liver disease
Connecticut Branches of biology
Fatty Liver Medical specialties
Hepatic Liver
High Definition Hepatology
Hormones Cell biology
Liver Commonly metabolic syndrome
Liver Cancer Disease
Liver Fibrosis Liver fibrosis
Los Angeles Cell sequencing technology
Macrophages Cell signaling
Metabolic Syndrome Cell sequencing technology
Metabolism
Mexico
Michigan
Myeloid
Nonalcoholic Steatohepatitis
Nucleic Acids
Organ
Prez
Qi
Receptors
Star
Texas
UCLA
Zhao

Semantics

Type Source Name
pathway BSID Developmental Biology
disease MESH disease progression
gene UNIPROT FNDC3A
gene UNIPROT JUN
drug DRUGBANK Guanosine
disease MESH liver fibrosis
gene UNIPROT TREM2
gene UNIPROT STAR
gene UNIPROT GUCY2C
disease MESH metabolic syndrome
disease DOID liver cancer
disease MESH liver cancer
disease DOID cirrhosis
disease MESH cirrhosis
pathway BSID Gene Expression
disease DOID fatty liver disease
disease MESH nonalcoholic steatohepatitis
gene UNIPROT SGSM3
pathway BSID Metabolism
gene UNIPROT ELAVL2
drug DRUGBANK Huperzine B

Original Article

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