Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study.

Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study.

Publication date: Aug 08, 2019

Background and Aims: It is not known whether inflammatory bowel disease (IBD) enhances the risk of Parkinson’s disease (PD) or whether PD diagnosis is the result of increased health care use. We determined the risk of developing PD among patients with IBD in terms of health care and medication use. Methods: A nationwide population-based study was conducted using claims data from the Korean National Health care Insurance service. From 2010 to 2013, patients with Crohn’s disease (CD) and ulcerative colitis (UC) were identified through both International Classification of Disease, Tenth Revision (ICD-10) and national rare intractable disease (RID) registration program codes. We compared 38,861 IBD patients with age and sex-matched non-IBD individuals at a ratio of 1:3. Patients with newly diagnosed PD were identified through both ICD-10 and RID codes. Results: The incidence of PD among patients with IBD was 49 per 100,000 person-years. The risk of developing PD in patients with IBD was significantly higher than controls even after adjustment for health care use (adjusted hazard ratio (aHR), 1.87; P

Park, S., Kim, J., Chun, J., Han, K., Soh, H., Kang, E.A., Lee, H.J., Im, J.P., and Kim, J.S. Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study. 21897. 2019 J Clin Med (8):8.

Concepts Keywords
Bowel Inflammatory bowel disease
Corticosteroid Colitis
ICD 10 RTT
Incidence Gastrointestinal tract disorders
Parkinson Abdominal pain
TNF Autoimmune diseases
Tumor Necrosis Factor Clinical medicine
Ulcerative Colitis Medicine
Medical specialties
IBD
Anti tumor necrosis
Crohn’s disease
Ulcerative colitis

Semantics

Type Source Name
gene UNIPROT TNF
gene UNIPROT AHR
gene UNIPROT PLXNA3
disease DOID ulcerative colitis
disease MESH ulcerative colitis
disease MESH diagnosis
gene UNIPROT ACAD8
disease DOID IBD
disease DOID Inflammatory Bowel Disease
disease MESH Inflammatory Bowel Disease

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