Pharmacogenomic Biomarkers in Docetaxel Treatment of Prostate Cancer: From Discovery to Implementation.

Pharmacogenomic Biomarkers in Docetaxel Treatment of Prostate Cancer: From Discovery to Implementation.

Publication date: Aug 08, 2019

Prostate cancer is the fifth leading cause of male cancer death worldwide. Although docetaxel chemotherapy has been used for more than fifteen years to treat metastatic castration resistant prostate cancer, the high inter-individual variability of treatment efficacy and toxicity is still not well understood. Since prostate cancer has a high heritability, inherited biomarkers of the genomic signature may be appropriate tools to guide treatment. In this review, we provide an extensive overview and discuss the current state of the art of pharmacogenomic biomarkers modulating docetaxel treatment of prostate cancer. This includes (1) research studies with a focus on germline genomic biomarkers, (2) clinical trials including a range of genetic signatures, and (3) their implementation in treatment guidelines. Based on this work, we suggest that one of the most promising approaches to improve clinical predictive capacity of pharmacogenomic biomarkers in docetaxel treatment of prostate cancer is the use of compound, multigene pharmacogenomic panels defined by specific clinical outcome measures. In conclusion, we discuss the challenges of integrating prostate cancer pharmacogenomic biomarkers into the clinic and the strategies that can be employed to allow a more comprehensive, evidence-based approach to facilitate their clinical integration. Expanding the integration of pharmacogenetic markers in prostate cancer treatment procedures will enhance precision medicine and ultimately improve patient outcomes.

Varnai, R., Koskinen, L.M., M”antyl”a, L.E., , Szabo, FitzGerald, L.M., and Sipeky, C. Pharmacogenomic Biomarkers in Docetaxel Treatment of Prostate Cancer: From Discovery to Implementation. 05162. 2019 Genes (Basel) (10):8.

Concepts Keywords
Basel Chemotherapy
Biomarkers Clinical medicine
Castration Branches of biology
Chemotherapy Biomarkers
Clinical Trials RTT
Docetaxel Genomics
Genetic Carbamates
Germline Taxanes
Heritability Pharmacogenomics
Metastatic Prostate cancer
Pharmacogenomic Docetaxel
Prostate Pharmacogenomic
Prostate Cancer Chemotherapy
Toxicity

Semantics

Type Source Name
gene UNIPROT AGRP
disease MESH death
disease DOID cancer
disease MESH cancer
pathway BSID Prostate cancer
disease DOID Prostate Cancer
disease MESH Prostate Cancer
drug DRUGBANK Docetaxel

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