α-Arbutin Protects Against Parkinson’s Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo.

α-Arbutin Protects Against Parkinson’s Disease-Associated Mitochondrial Dysfunction In Vitro and In Vivo.

Publication date: Aug 10, 2019

Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by the progressive loss of dopaminergic neurons in substantia nigra. The underlying mechanisms of PD pathogenesis have not been fully illustrated and currently PD remains incurable. Accumulating evidences suggest that mitochondrial dysfunction plays pivotal role in the dopaminergic neuronal death. Therefore, discovery of novel and safe agent for rescuing mitochondrial dysfunction would benefit PD treatment. Here we demonstrated for the first time that α-Arbutin (Arb), a natural polyphenol extracted from Ericaceae species, displayed significant protective effect on the rotenone (Rot)-induced mitochondrial dysfunction and apoptosis of human neuroblastoma cell (SH-SY5Y). We further found that the neuroprotective effect of Arb was associated with ameliorating oxidative stress, stabilizing of mitochondrial membrane potential, and enhancing adenosine triphosphate production. To investigate the underlying mechanism, we checked the AMP-activated protein kinase and autophagy pathway and we found that both were involved in the neuroprotection of Arb. Moreover, we explored the protective effect of Arb in drosophila PD model and found that Arb rescued parkin deficiency-induced motor function disability and mitochondrial abnormality of drosophila. Taken together, our study demonstrated that Arb got excellent neuroprotective effect on PD models both in vitro and in vivo and Arb might serve as a potent therapeutic agent for the treatment of PD.

Concepts Keywords
Adenosine Triphosphate Mitochondrial dysfunction
AMP Parkin deficiency
Apoptosis Branches of biology
Autophagy Medical specialties
Dopaminergic Senescence
Drosophila Neurology
Ericaceae Programmed cell death
Kinase Neuroprotection
Membrane Potential Parkin
Mitochondrial Neurodegeneration
Mitochondrial Membrane Autophagy
Motor Disability Mitochondrion
Movement Disorder Rotenone
Neuroblastoma Apoptosis
Neurodegenerative
Neurons
Neuroprotection
Neuroprotective
Oxidative Stress
Parkin
Parkinson
Pathogenesis
Polyphenol
Progressive
Rotenone
Species
Substantia Nigra

Semantics

Type Source Name
gene UNIPROT PRKN
drug DRUGBANK Profenamine
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK ATP
pathway BSID Oxidative Stress
disease MESH oxidative stress
disease DOID neuroblastoma
disease MESH neuroblastoma
pathway BSID Apoptosis
drug DRUGBANK Rotenone
disease MESH death
disease MESH movement disorder
drug DRUGBANK Arbutin

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