Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.

Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.

Publication date: Aug 08, 2019

Parkinson disease (PD) is the second most common neurodegenerative disease associated with aging. Dopaminergic neuronal degeneration and α-synuclein aggregation are commonly found in PD brain. Oxidative damage and inflammation often are considered as etiological factors of PD, although the detailed mechanisms still remain unknown. Gender and aging are two important risk factors to PD, and gene mutations and certain environmental factors have been implicated in this disease. The current study employed PTEN-induced putative kinase -1 (PINK1) knockout (KO) rats, since mutations in PINK-1 lead to familial PD. We evaluated the oxidative damage in the brain of PINK1 KO rats, and we used MRI and MRS to measure the ventricle sizes and neurochemical metabolite profiles in these rats as a function of age and gender. Distinct gender- and age-related alterations were found. The results are discussed with respect to the suitabililty of this unique rat as a faithful model of known characteristics of PD.

Ren, X., Hinchie, A., Swomley, A., Powell, D.K., and Butterfield, D.A. Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease. 21902. 2019 Free Radic Biol Med.

Concepts Keywords
Aging Disease
Brain Branches of biology
Dopaminergic Senescence
Etiological Factors Cell biology
Gender PINK1
Inflammation Geriatrics
Kinase Neuroscience
Knockout Parkin
Metabolite Neurodegeneration
MRI Oxidative stress
Neurodegenerative MRI
Oxidative Damage
Parkinson
Parkinson Disease
PINK1
PTEN
Striatum
Ventricle
Ventricular

Semantics

Type Source Name
disease MESH Edema
gene UNIPROT CYREN
gene UNIPROT PTEN
disease MESH risk factors
disease MESH inflammation
pathway BSID Aging
disease MESH aging
disease DOID neurodegenerative disease
disease MESH neurodegenerative disease
disease DOID Parkinson disease
disease MESH Parkinson disease
gene UNIPROT PINK1
pathway BSID Oxidative Damage

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