Salivary alpha-synuclein as a biomarker for Parkinson’s disease: a systematic review.

Salivary alpha-synuclein as a biomarker for Parkinson’s disease: a systematic review.

Publication date: Aug 10, 2019

The search for a reliable, early-disease biomarker for Parkinson’s disease (PD) that reflects underlying pathology is a high priority in PD research. Salivary alpha-synuclein (α-Syn) is an easily accessible biomarker for PD with promising results. Our aim was to evaluate the performance of salivary α-Syn as a diagnostic biomarker of PD. We identified 476 studies through a systematic literature review according to PRISMA guidelines. Finally, eight studies reporting data on salivary α-Syn were included in the review (1240 participants). The quality of studies was assessed by Newcastle-Ottawa scale. (1) Three studies showed that the total α-Syn levels were significantly lower in PD patients compared to healthy controls, while in another five there was no significant association. (2) In some studies, total salivary α-Syn was associated with demographic and clinical features; however, no consistent pattern emerged. In one study, total α-Syn levels were associated with poor cognitive performance in PD patients. (3) Four studies showed a higher salivary oligomeric α-Syn and oligomeric α-Syn/total α-Syn ratio in PD compared to healthy controls, while in another four there was no association. (4) One study concluded that genetic polymorphisms may influence total salivary α-Syn in PD patients. Taken together, the potential of salivary total α-Syn as a PD biomarker is still uncertain, whereas salivary oligomeric α-Syn appears quite promising. Pre-analytical and analytical factors of included studies were important limitations to justify the introduction of salivary α-Syn into clinical practice.

Bougea, A., Koros, C., and Stefanis, L. Salivary alpha-synuclein as a biomarker for Parkinson’s disease: a systematic review. 21900. 2019 J Neural Transm (Vienna).

Concepts Keywords
Biomarker Reliable early disease
Cognitive Branches of biology
Demographic Medicine
Genetic Polymorphisms Clinical medicine
Newcastle Biomarkers
Ottawa Peripheral membrane proteins
Parkinson Cell biology
Pathology RTT
Systematic Review Biotechnology
Vienna Alpha-synuclein
Salivary gland
Parkinson’s disease
Saliva testing
Alpha

Semantics

Type Source Name
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT SYNM
gene UNIPROT SNCA

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