SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway.

SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway.

Publication date: Aug 08, 2019

SHARPIN, as a tumor-associated gene, is involved in the metastatic process of many kinds of tumors. Herein, we studied the function of SHARPIN in melanoma metastasis and the relevant molecular mechanisms. We found that SHARPIN expression was increased in melanoma tissues and activated the process of proliferation, migration and invasion in vitro and in vivo, resulting in a poor prognosis of the disease. Functional analysis demonstrated that SHARPIN promoted melanoma migration and invasion by regulating Rap1 and its downstream pathways, including p38 and JNK/c-Jun. Rap1 activator (8-pCPT-2′-O-Me-cAMP) and inhibitor (ESI-09 and farnesylthiosalicylic acid-amide) treatments could partially rescue invasion and migration of tumor cells. Additionally, SHARPIN expression in cell lines and public datasets also indicated that molecules other than BRAF and N-RAS may contribute to SHARPIN activation. In conclusion, our broad-in-depth work suggested that SHARPIN promoted melanoma development via p38 and JNK/c-Jun pathways through upregulating Rap1 expression.

Zhou, S., Liang, Y., Zhang, X., Liao, L., Yang, Y., Ouyang, W., and Xu, H. SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway. 23717. 2019 J Invest Dermatol.

Concepts Keywords
Acid Tumor
Amide Tumors
BRAF Invasion migration tumor
CAMP SHARPIN melanoma metastasis
Gene Cancer pathology
Inhibitor Oncology
JNK Medicine
Melanoma Medical specialties
Metastasis Health
Metastatic Rap1
P38 Melanoma
Prognosis Invasion
RAS Metastasis
Tumor C-jun
Vivo

Semantics

Type Source Name
disease MESH development
drug DRUGBANK Rasagiline
gene UNIPROT BRAF
gene UNIPROT PI3
gene UNIPROT CHAMP1
gene UNIPROT CAMP
drug DRUGBANK Cyclic Adenosine Monophosphate
gene UNIPROT JUN
gene UNIPROT RNF19A
gene UNIPROT CRK
gene UNIPROT AHSA1
gene UNIPROT GRAP2
gene UNIPROT POLDIP2
gene UNIPROT RABGEF1
gene UNIPROT TERF2IP
disease MESH metastasis
disease MESH tumor
pathway BSID Rap1 signaling pathway
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
gene UNIPROT SHARPIN

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *