The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies.

The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies.

Publication date: Aug 12, 2019

With a number of antibody-drug conjugates (ADCs) approved for clinical use as targeted cancer therapies and numerous candidates in clinical trials, the field of ADCs is emerging as one of the frontiers in biomedical research, particularly in the area of cancer treatment. Chemists, biologists and clinicians, among other scientists, are partnering their expertise to improve their design, synthesis, efficacy and precision as they strive to advance this paradigm of personalized and targeted medicine to treat cancer patients more effectively and to expand its scope to other indications. Just as Alexander Fleming’s penicillin, and the myriad other bioactive natural products that followed its discovery and success in the clinic, ignited a revolution in medicine after the Second World War, so did calicheamicin γ , and other highly potent naturally occurring antitumor agents, play a pivotal role in enabling the advent of this new paradigm of “biological-small molecule hybrid” medical intervention. Today there are four clinically approved drugs from the ADC paradigm, Mylotarg, Adcetris, Kadcyla and Besponsa, in order of approval, the first and the last of which carry the same calicheamicin γ -derived payload. Covering oncological applications, and after a brief history of the emergence of the field of antibody-drug conjugates triggered more than a century ago by Paul Ehrlich’s “magic bullet” concept, this Review is primarily focusing on the chemical synthesis aspects of the ADCs multidisciplinary research enterprise.

Nicolaou, K.C. and Rigol, S. The Role of Organic Synthesis in the Emergence and Development of Antibody-Drug Conjugates as Targeted Cancer Therapies. 05167. 2019 Angew Chem Int Ed Engl (58):33.

Concepts Keywords
Adcetris Chemical
ADCs Cancer treatments
Alexander Fleming Antibody-drug conjugates
Angew Chem Clinical medicine
Antibody Drugs
Bioactive Calicheamicin
Biomedical Gemtuzumab ozogamicin
Chemical Synthesis Brentuximab vedotin
Clinical Trials Inotuzumab ozogamicin
Hybrid Targeted therapy
Natural Products Trastuzumab emtansine
Oncological ADC
Paradigm
Paul Ehrlich
Penicillin
Small Molecule
Targeted Therapies

Semantics

Type Source Name
drug DRUGBANK Gemtuzumab ozogamicin
gene UNIPROT AZIN2
gene UNIPROT GADL1
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Spinosad
disease DOID Cancer
disease MESH Cancer
disease MESH Development

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