Estrogen improves Parkinson’s disease symptoms

Estrogen improves Parkinson’s disease symptoms

Publication date: Aug 13, 2019

Credit: Rajsombath et al. , JNeurosci 2019 Brain-selective estrogen treatment improves the symptoms of Parkinson’s disease in male mice, according to new research published in JNeurosci.

Silke Nuber and colleagues at Harvard Medical School treated mouse models of Parkinson’s disease with brain-selective estrogen and compared the motor performance of males and females before and after treatment.

In male mice, the estrogen treatment reduced α-synuclein breakdown and buildup and helped with severe symptoms, suggesting that estrogen could be a viable treatment option for Parkinson’s patients with low estrogen levels.

Concepts Keywords
Brain Disease
Confocal Microscopy Hormones
Estrogen Endocrine system
Fair Dealing Organ systems
Harvard Hepatotoxins
Menopausal Prolactin releasers
Mice Estrogens
Neurons Estranes
Parkinson Phenols
Pathology Estrogen deprivation therapy

Semantics

Type Source Name
disease DOID Syndrome
disease MESH Syndrome
gene UNIPROT SLC35G1
gene UNIPROT DESI1
disease MESH men
disease MESH Estrogen
gene UNIPROT PLXNA3
disease MESH death

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