A Trial of tPCS on Parkinson’s Disease OFF State

A Trial of tPCS on Parkinson’s Disease OFF State

Publication date: Aug 13, 2019

A significant number of patients with Parkinson’s disease (PD) face motor fluctuations even after repeated titration of the dosing of Levodopa. Dealing with OFF state really becomes problematic for them. Aggravation of bradykinesia, rigidity, tremor and gait difficulty are the common problems in OFF state. Studies are going on drugs like Apomorphine as rescue therapy in OFF state. Recently there are studies with Noninvasive brain stimulation, as an evolving therapeutic option in different neurodegenerative diseases. In this study, the investigators are to evaluate the efficacy of transcranial pulsed current stimulation (tPCS) in the OFF state in PD patients. The investigators will give stimulation via tPCS (active/sham). EEG, Kinematic measurement of upper limb movement via KinArm, Unified Parkinson’s Disease Rating Scale (UPDRS) scoring will be done and gait will be assessed via Gait Carpet – pre and post-stimulation. The investigators will evaluate the effectiveness of tPCS as a single modality or in combination with Levodopa in managing OFF state of PD.

Concepts Keywords
Actuators Parkinsonism
Apomorphine Branches of biology
Bradykinesia Medicine
Brain Medical specialties
Canada Terrestrial locomotion
Carpet Neurophysiology
EEG Neurotechnology
Electric Current TPCS
Electrode Rehabilitation medicine
Electroencephalography Gait analysis
Electromagnetic Electroencephalography
Electrophysiological
Gait
Gait Analysis
Informed Consent
Kinematics
Levodopa
Mat
Motor Cortex
NaCl
Nautilus
Neurodegenerative Diseases
Neurological Examination
Parkinson
Parkinsonism
Perturbations
Saline
Sponge
Supplementary Motor Area
Titration
Tremor
Walks
Western University
Wheelchair
Wireless
Zeno

Semantics

Type Source Name
disease DOID face
gene UNIPROT ELOVL6
gene UNIPROT FANCE
drug DRUGBANK Levodopa
disease MESH bradykinesia
disease MESH tremor
disease MESH gait
drug DRUGBANK Apomorphine
disease MESH neurodegenerative diseases
pathway BSID Neurodegenerative Diseases
gene UNIPROT DESI1
gene UNIPROT SLC35G1
disease MESH syndromes
gene UNIPROT NR4A2
gene UNIPROT ALG3
disease MESH Parkinson Disease
disease DOID Parkinson Disease

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