Asthma from immune pathogenesis to precision medicine.

Asthma from immune pathogenesis to precision medicine.

Publication date: Aug 03, 2019

Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients.

Khalaf, K., Paoletti, G., Puggioni, F., Racca, F., De Luca, F., , Giorgis, Canonica, G.W., and Heffler, E. Asthma from immune pathogenesis to precision medicine. 05187. 2019 Semin Immunol.

Concepts Keywords
Asthma Disease
Pathogenesis Pathogenesis asthma
Phenotypes Adaptive immune system
Phenotypic Immunology
Precision Medicine Immunity

Semantics

Type Source Name
drug DRUGBANK Tropicamide
pathway BSID Asthma
disease DOID Asthma
disease MESH Asthma

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