G-protein coupled receptor 40 expression in human melanoma – correlation with tumor thickness, AJCC stage and survival.

G-protein coupled receptor 40 expression in human melanoma – correlation with tumor thickness, AJCC stage and survival.

Publication date: Aug 29, 2019

In melanoma, preclinical data suggests a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G-protein coupled receptor GPR40, was identified in melanoma cells.

Aim of this study was to investigate GPR40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker.

114 tissue sections of nevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti-GPR40. The staining was evaluated, using the immunoreactivity scoring system. Compared to nevi, primary melanoma and melanoma metastasis showed significant higher levels of GPR40 (P

The present study identified GPR40 as a novel target molecule in melanoma. First evidence for a potential role of the receptor in tumor progression and metastases was found and it could be demonstrated that GPR40 expression is negatively correlated with patient’s survival. This article is protected by copyright. All rights reserved.

Kleemann, J., , Hrgovic, Kleimann, P., Ter-Nedden, J., Glaser, M., Steinhorst, K., H”arle, K., M”uller, J., Kaufmann, R., Kippenberger, S., and Meissner, M. G-protein coupled receptor 40 expression in human melanoma – correlation with tumor thickness, AJCC stage and survival. 23949. 2019 J Eur Acad Dermatol Venereol.

Concepts Keywords
Aim Epigenetics and melanoma
AJCC Breslow’s depth
Correlation Metastasis
Free Fatty Acids RTT
Immunohistochemically Melanoma
Immunoreactivity Health
Melanoma Medicine
Metastases Cancer
Metastasis Primary melanoma GPR40
Molecule
Nevi
Polyunsaturated Fatty Acids
Receptor
Staining
Tumor

Semantics

Type Source Name
disease MESH metastasis
disease MESH nevi
gene UNIPROT DNMT1
gene UNIPROT CD69
pathway BSID Fatty acids
disease MESH tumor
pathway BSID Melanoma
disease DOID melanoma
gene UNIPROT FFAR1
disease MESH melanoma

Original Article

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