Subtle Changes in Speech Mark Pre-symptomatic Huntington’s, Study Finds

Subtle Changes in Speech Mark Pre-symptomatic Huntington’s, Study Finds

Publication date: Sep 03, 2019

This post was originally published on this site People at a pre-symptomatic, or premanifest, stage of Huntington’s disease (HD) have subtle speech alterations that may be used as a marker to evaluate new therapies intended to stop or slow disease progression before it becomes too debilitating. The study with that recent research, -Speech in prodromal and symptomatic Huntington’s disease as a model of measuring onset and progression in dominantly inherited neurodegenerative diseases,” was published in the journal Neuroscience & Biobehavioral Reviews. However, pinpointing the specific speech marks that distinguish people with premanifest HD from healthy individuals remains unclear, in part due to the lack of neuroimaging studies that could help draw a link between speech changes and brain degeneration. -Stronger evidence is needed to establish the sensitivity and reliability of speech markers in detecting pathophysiological changes in [premanifest] HD and evaluating the effectiveness of pharmacological therapy,” the researchers wrote. The post Subtle Changes in Speech Mark Pre-symptomatic Huntington’s, Study Finds appeared first on Huntington’s Disease News. The post Subtle Changes in Speech Mark Pre-symptomatic Huntington’s, Study Finds appeared first on BioNewsFeeds.

Concepts Keywords
Amplitude Amyotrophic lateral sclerosis
Brain Neuroscience
Chorea Speech
Clinical Trials Dysarthria
Cognitive Chorea
Dysarthria RTT
Fine Motor Skills Rare diseases
Genetic Disorder Language
Huntington Human communication
Loudness Communication disorders
Meta Analysis Organ systems
Neurodegeneration Neurological disorders
Neurodegenerative Neurodegenerative diseases
Neurodegenerative Diseases Symptoms chorea
Neuroimaging Speech timing disease
Pathophysiological
Pharmacological
Prodromal
Stronger
Syllabic
Vocal Cord
Vowel

Semantics

Type Source Name
gene UNIPROT DESI1
gene UNIPROT MARK1
disease DOID chorea
disease MESH chorea
disease MESH genetic disorder
pathway BSID Neurodegenerative Diseases
disease MESH neurodegenerative diseases
disease MESH disease progression
gene UNIPROT MAP6
gene UNIPROT SLC35G1
gene UNIPROT AICDA
disease MESH dysarthria
gene UNIPROT FURIN
disease DOID brain degeneration

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