Targeting Inflammatory Th17 Cells to Slow MS Disability Possible with Fewer Side Effects, Study Suggests

Targeting Inflammatory Th17 Cells to Slow MS Disability Possible with Fewer Side Effects, Study Suggests

Publication date: Sep 04, 2019

A molecule that regulates the production of IL-17 in Th17 cells, called retinoic acid t (RORγt), has caught scientists’ attention before as a potential target for treating autoimmune diseases. Their work showed that REV-ERBα, a molecule known to suppress the activity of RORγt by competing in a variety of processes for the same binding site on the DNA of cells, also competed for that site with Th17 cells. When the team specifically increased the levels of REV-ERBα in Th17 cells grown in the lab, both RORγt activity and Il-17 production were suppressed. -REV-ERBα is induced during Th17 cell differentiation and directly competes with RORγt by binding to [specific] sites to repress the expression of key Th17 cell signature genes,” the scientists wrote. Researchers believe their work suggests that boosting REV-ERBα activity through SR9009 lowers inflammation, and without harming the immune system in ways that current RORγt suppressive efforts do.

Concepts Keywords
Autoimmune Disease MS rheumatoid arthritis
Autoimmune Diseases MS
ERB Mediated autoimmune diseases
IL 17 Mediated autoimmune disease
Il 17 Medical specialties
Immune System Medicine
Inflammation Branches of biology
Interleukin 17 RTT
Mice Immunology
Molecule T cells
Myelin Immune system
Nerve Cells Interleukins
Nuclear Receptor Interleukin 17
Psoriasis Arthritis
Retinoic Acid Autoimmunity
Rheumatoid Arthritis
Side Effects
T Cell
T Cells
Th17
Th17 Cells
Virus

Semantics

Type Source Name
disease MESH inflammation
disease MESH sclerosis
pathway BSID Immune System
disease MESH autoimmune diseases
disease DOID autoimmune disease
gene UNIPROT IL17A
disease MESH development
disease MESH rheumatoid arthritis
disease DOID rheumatoid arthritis
pathway BSID Rheumatoid arthritis
drug DRUGBANK Tretinoin
gene UNIPROT MAGEE1
gene UNIPROT REST
gene UNIPROT LAT2
gene UNIPROT PAGR1
gene UNIPROT GAST
pathway BSID Release
disease MESH experimental autoimmune encephalomyelitis
pathway BSID Th17 cell differentiation
pathway BSID Gene Expression
disease MESH psoriasis
disease DOID psoriasis

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *