Publication date: Sep 06, 2019
Credit: CC0 Public Domain Researchers from the brain cognition and plasticity group of the Bellvitge Biomedical Research Institute (IDIBELL) and the Neuroscience Institute of the University of Barcelona (UBNeuro) have led an innovative study that identifies modifications in the connectivity of cerebral white matter associated with the heterogeneous nature of apathy in Huntington’s disease (HD), making it possible to use this syndrome as a biomarker of disease progression.
“Our goal was to study apathy as a multidimensional syndrome and explore, for the first time, the relationship between different subtypes of apathy and white matter connectivity in Huntington’s disease,” says Dr. Estela CcE0mara, lead author.
“Distinguishing the white matter configuration of each subtype in HD can allow us to define disease profiles across the spectrum of apathy, facilitating its diagnosis and treatment,” adds Audrey DePaepe, Fullbright student and first author of the study.
E. De Paepe et al, White matter cortico-striatal tracts predict apathy subtypes in Huntington’s disease, NeuroImage: Clinical (2019).