Apathy as an indicator of progression in Huntington’s disease

Apathy as an indicator of progression in Huntington’s disease

Publication date: Sep 06, 2019

Credit: CC0 Public Domain Researchers from the brain cognition and plasticity group of the Bellvitge Biomedical Research Institute (IDIBELL) and the Neuroscience Institute of the University of Barcelona (UBNeuro) have led an innovative study that identifies modifications in the connectivity of cerebral white matter associated with the heterogeneous nature of apathy in Huntington’s disease (HD), making it possible to use this syndrome as a biomarker of disease progression.

“Our goal was to study apathy as a multidimensional syndrome and explore, for the first time, the relationship between different subtypes of apathy and white matter connectivity in Huntington’s disease,” says Dr. Estela CcE0mara, lead author.

“Distinguishing the white matter configuration of each subtype in HD can allow us to define disease profiles across the spectrum of apathy, facilitating its diagnosis and treatment,” adds Audrey DePaepe, Fullbright student and first author of the study.

E. De Paepe et al, White matter cortico-striatal tracts predict apathy subtypes in Huntington’s disease, NeuroImage: Clinical (2019).

Concepts Keywords
Apathy Brain cognition plasticity
Barcelona Biomarker
Biomarker Syndrome
Brain Narcissism
CC0 Emotions
Cognition Learning disabilities
Cognitive Abnormal psychology
Differential Diagnosis Apathy
Fair Dealing Articles
Heterogeneity Psychiatric diagnosis
Huntington Clinical medicine
Neurodegeneration Medicine
Neurodegenerative Disorders Apathy multidimensional syndrome
Push Start
White Matter


Type Source Name
disease MESH syndrome
disease MESH disease progression
disease MESH neurodegenerative disorders
disease MESH diagnosis
disease MESH rare disease
disease DOID syndrome
disease MESH Apathy


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