New Gene-editing Tool SATI Can Target Different Kinds of Disease-causing Mutations, Mouse Study Suggests

New Gene-editing Tool SATI Can Target Different Kinds of Disease-causing Mutations, Mouse Study Suggests

Publication date: Sep 05, 2019

This post was originally published on this site A new gene editing method allows researchers to target many different kinds of disease-causing mutations in multiple cell types, which could have implications for genetic disorders such as Huntington’s disease, a study suggests. The new method was described in the journal Cell Research in a study, titled -Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. ” In the new study, they expanded on HITI and developed SATI (intercellular linearized Single homology Arm donor mediated intron-Targeting Integration), which allows for more types of mutations to be edited. -We sought to create a versatile tool to target these non-coding regions of the DNA, which would not affect the function of the gene, and enable the targeting of a broad range of mutations and cell types,” one of the study’s co-authors, Mako Yamamoto, PhD, a postdoctoral fellow at the Salk Institute, said in a news release. The post New Gene-editing Tool SATI Can Target Different Kinds of Disease-causing Mutations, Mouse Study Suggests appeared first on Huntington’s Disease News. The post New Gene-editing Tool SATI Can Target Different Kinds of Disease-causing Mutations, Mouse Study Suggests appeared first on BioNewsFeeds.

Concepts Keywords
Aging LMNA
Brain Progeroid syndromes
Cas9 CRISPR
Coding Region Cas9
CRISPR Genetic engineering
DNA Genome editing
Gene Biological engineering
Gene Editing Emerging technologies
Genetic Life sciences
Genetic Diseases Biotechnology
Genetic Disorders Branches of biology
Genetic Modification Target kinds disease
Genome Models progeria
Genome Editing Disease
Homology Details cellular systems
Huntington Cut
Intron Genome editing tools
LMNA
Mako
Mutation
Nerve Cells
Organism
PhD
Postdoctoral Fellow
Progeria
Protein
Salk Institute
Spleen
Tailor
Vivo

Semantics

Type Source Name
disease MESH progeria
disease DOID progeria
disease MESH premature aging
pathway BSID Release
gene UNIPROT PDC
pathway BSID Gene Expression
gene UNIPROT LMNA
disease MESH aging
pathway BSID Aging
pathway BSID DNA Repair
drug DRUGBANK Tropicamide
gene UNIPROT CTNND1
gene UNIPROT BCAR1
gene UNIPROT CSE1L
disease DOID genetic disease
gene UNIPROT DESI1
gene UNIPROT SLC35G1
disease MESH genetic disorders

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