Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease.

Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease.

Publication date: Jan 27, 2019

Parkinson’s disease (PD) affects 2-3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with putative connections to prefrontal cortices. We then investigated potential differences in the size and shape of the thalamus in PD, and how morphology and functional connectivity relate to clinical variables. Our data demonstrate that PD is associated with increases in functional connectivity between motor subdivisions of the thalamus and the supplementary motor area, and between prefrontal thalamic subdivisions and nuclei of the basal ganglia, anterior and dorsolateral prefrontal cortices, as well as the anterior and paracingulate gyri. These results suggest that PD is associated with increased functional connectivity of subdivisions of the thalamus which may be indicative alterations to basal ganglia-thalamocortical circuitry.

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Owens-Walton, C., Jakabek, D., Power, B.D., Walterfang, M., Velakoulis, D., van Westen, D., Looi, J.C.L., Shaw, M., and Hansson, O. Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease. 22198. 2019 PLoS One (14):9.

Concepts Keywords
Basal Ganglia Brain
Cerebral Cortex Motor system
Dopaminergic Basal ganglia
Functional Connectivity Thalamus
Gyri Cerebral cortex
Indicative Prefrontal cortex
Morphology Substantia nigra
Motor Cortices Thalamocortical radiations
Neurons Direct pathway
Nuclei
Parkinson
Prefrontal
Substantia Nigra
Supplementary Motor Area
Thalamic
Thalamus

Semantics

Type Source Name
gene UNIPROT ABCC8
gene UNIPROT LAT
gene UNIPROT SNAP25
gene UNIPROT ARID1A
gene UNIPROT EDNRA
gene UNIPROT TNFSF14
gene UNIPROT IK
gene UNIPROT ANKHD1
gene UNIPROT STK26
gene UNIPROT SGSM3
drug DRUGBANK Esomeprazole
gene UNIPROT PLXNA3
disease MESH visual
gene UNIPROT CPVL
gene UNIPROT VHLL
gene UNIPROT CARD8
gene UNIPROT DEPP1
gene UNIPROT GOPC
gene UNIPROT TBATA
gene UNIPROT DNER
gene UNIPROT BTG3
drug DRUGBANK Flunarizine
gene UNIPROT COIL
gene UNIPROT TRIO
gene UNIPROT ASPSCR1
drug DRUGBANK Levodopa
disease MESH movement disorders
disease MESH dementia
disease DOID dementia
disease MESH diagnosis
drug DRUGBANK Ethanol
disease MESH developmental disability
disease DOID Stroke
disease MESH Stroke
drug DRUGBANK Methylergometrine
gene UNIPROT SLC35G1
gene UNIPROT DESI1
gene UNIPROT GTF2A1L
gene UNIPROT ELAVL2
drug DRUGBANK Huperzine B
drug DRUGBANK gamma-Aminobutyric acid
drug DRUGBANK Dopamine
drug DRUGBANK Oxygen
gene UNIPROT REST
gene UNIPROT CYREN
gene UNIPROT ELK3
gene UNIPROT EPHB1
gene UNIPROT SLC6A2
disease MESH cognitive impairment
disease MESH resting tremor
disease MESH neurodegenerative disorder
gene UNIPROT PDC
drug DRUGBANK Tacrine
gene UNIPROT TNIP1
gene UNIPROT MARK1

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