MC1R Variation in a New Mexico Population.

MC1R Variation in a New Mexico Population.

Publication date: Sep 05, 2019

The Melanocortin 1 Receptor (MC1R) contributes to pigmentation, an important risk factor for developing melanoma. Evaluating single nucleotide polymorphisms (SNPs) in MC1R and association with race/ethnicity, skin type, and perceived cancer risk in a New Mexico population will elucidate the role of MC1R in a multi-cultural population.

We genotyped MC1R in 191 New Mexicans attending a primary care clinic in Albuquerque. We obtained individuals’ self-identified race/ethnicity, skin type, and perceived cancer risk. We defined genetic risk as carriage of any one or more of the nine most common SNPs in MC1R.

We found that one MC1R SNP, R163Q (rs885479), was identified in 47.6 percent of self-identified Hispanics and 12.9 percent of non-Hispanic whites, making Hispanics at higher “genetic risk” (as defined by carrying one of the MC1R common variants). When we deleted R163Q from analyses, Hispanics were no longer at higher genetic risk (33.3 percent) compared to NHW (48.3 percent), consistent with melanoma rates, tanning ability and lower perceived risk. Hispanics had a perceived risk significantly lower than non-Hispanic whites (NHW) and a non-significant better tanning ability than NHW.

The R163Q variant in MC1R may not be a risk factor for melanoma among New Mexican Hispanics. This suggestion points to the need to carefully interpret genetic risk factors among specific populations.

This study may modify the way melanoma risk is calculated for Hispanics.

White, K.A.M., Dailey, Y.T., Guest, D.D., Zielaskowski, K., Robers, E., Sussman, A., Hunley, K., Hughes, C.R., Schwartz, Kaphingst, K.A., Buller, D.B., Hay, J.L., and Berwick, M. MC1R Variation in a New Mexico Population. 24027. 2019 Cancer Epidemiol Biomarkers Prev.

Concepts Keywords
Albuquerque Percent consistent melanoma
Genetic Branches of biology
Hispanic Hair color
MC1R Skin pigmentation
Melanoma Melanocortin 1 receptor
Mexican Genetic genealogy
Mexico Melanoma
Primary Care Clinic Human skin color
Risk Factor Single-nucleotide polymorphism
Single Nucleotide Polymorphisms SNP
Skin Type
SNP
SNPs
Tanning

Semantics

Type Source Name
drug DRUGBANK Tropicamide
disease MESH multi
disease DOID cancer
disease MESH cancer
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease MESH risk factor
gene UNIPROT MC1R

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