New compound promotes healing of myelin in nervous system disorders

New compound promotes healing of myelin in nervous system disorders

Publication date: Sep 06, 2019

Credit: Scientists have developed a compound that successfully promotes rebuilding of the protective sheath around nerve cells that is damaged in conditions such as multiple sclerosis. Researchers at Oregon Health Science University have already started to apply the compound on a rare population of macaque monkeys at the Oregon National Primate Research Center at OHSU who develop a disease that is similar to MS in humans. In that study, scientists discovered that a molecule called hyaluronic acid, or HA, accumulates in the brains of patients with MS. Further, the scientists linked this accumulation of HA to the failure of cells called oligodendrocytes to mature. Subsequent studies led by the Sherman lab showed that HA is broken down into small fragments in multiple sclerosis lesions by enzymes called hyaluronidases. In collaboration with Stephen Back, M. D., Ph. D., a professor of pediatrics in the OHSU School of Medicine, Sherman discovered that the fragments of HA generated by hyaluronidases send a signal to immature oligodendrocytes not to turn on their myelin genes. For the past decade, an international team of researchers led by OHSU has been working to develop a compound that neutralizes the hyaluronidase in the brains of patients with MS and other neurodegenerative diseases, thereby reviving the ability of progenitor cells to mature into myelin-producing oligodendrocytes.

Concepts Keywords
Alzheimer Neuroscience
Axons Polydendrocytes
Brain Oligodendrocyte progenitor cell
Brain Damage Nerve injury
Cerebral Palsy Oligodendrocyte
Clinical Trials Remyelination
Dementia Organ systems
Encephalomyelitis Myelin
Fair Dealing Nervous system
Hyaluronic Acid Glial cells
Hyaluronidase Branches of biology
Japanese Macaque Nervous system disorders
Macaque Similar multiple sclerosis
Mice Conditions multiple sclerosis
Molecule MS
Multiple Sclerosis Japanese macaque encephalomyelitis
Myelin Flavonoida class chemicals
Myelination
Nerve
Nerve Cell
Nervous System
Neurodegenerative Diseases
Neuron
Oligodendrocytes
Oregon
Pediatrics
Primate
Primates
Stroke

Semantics

Type Source Name
disease DOID encephalomyelitis
disease MESH encephalomyelitis
disease MESH growth
pathway BSID Neurodegenerative Diseases
disease MESH neurodegenerative diseases
drug DRUGBANK Hyaluronidase
gene UNIPROT EHD1
disease DOID cerebral palsy
disease MESH cerebral palsy
disease DOID dementia
disease MESH dementia
disease DOID stroke
disease MESH stroke
gene UNIPROT MAGEE1
drug DRUGBANK Hyaluronic acid
gene UNIPROT LAT2
drug DRUGBANK Nonoxynol-9
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease MESH nervous system disorders

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