Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson’s Disease Animal Model.

Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson’s Disease Animal Model.

Publication date: Sep 06, 2019

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Among its non-motor symptoms, sleep disorders are extremely common, being linked to cognitive and memory disruption. The microenvironment, particularly the extracellular matrix (ECM), is deeply involved in memory consolidation as well as in neuropathological processes, such as inflammation, damage to the blood-brain barrier and neuronal death. To better understand ECM dynamics in PD memory disturbances, we investigated the orchestrated expression of Mmps (Mmp-3, Mmp-7, and Mmp-9) and their modulators (Reck and Timp-3) in a rotenone-induced PD model. Also, we introduced an additional intervention in the memory process through rapid eye movement sleep deprivation (REMSD). We observed a REMSD-induced trend in reversing the memory impairment caused by rotenone administration. Associated to this phenotype, we observed a significant increase in Mmp-7/Reck and Mmp-9/Reck mRNA expression ratio in the substantia nigra and Mmp-9/Reck ratio in the hypothalamus. Moreover, the positive correlation of Mmp/Reck expression ratios between the substantia nigra and the striatum, observed upon rotenone infusion, was reversed by REMSD. Taken together, our results suggest a potential orchestrated association between an increase in Mmp-7 and Mmp-9/Reck expression ratios in the substantia nigra and a possible positive effect on cognitive performance in subjects affected by PD.

Spindola, A., Targa, A.D.S., Rodrigues, L.S., Winnischofer, S.M.B., Lima, M.M.S., Sogayar, M.C., and Trombetta-Lima, M. Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson’s Disease Animal Model. 22223. 2019 Mol Neurobiol.

Concepts Keywords
Blood Brain Barrier Substantia nigra
Cognitive Parkinson’s disease
Correlation RECK
ECM Rotenone
Extracellular Matrix Matrix metalloproteinases
Hypothalamus Matrix metallopeptidase
Inflammation Metalloproteins
Infusion Branches of biology
Memory Toxins
Memory Consolidation Enzymes
Microenvironment Disorders
MRNA
Neurodegenerative Disorder
Neuropathological
Parkinson
Phenotype
Rotenone
Sleep Disorders
Striatum
Substantia Nigra

Semantics

Type Source Name
disease MESH neurodegenerative disorder
gene UNIPROT RECK
disease MESH sleep disorders
disease MESH sleep deprivation
drug DRUGBANK Rotenone
gene UNIPROT MMP9
gene UNIPROT TIMP3
gene UNIPROT MMP7
gene UNIPROT MMP3
drug DRUGBANK Tropicamide
disease MESH death
gene UNIPROT MAGEE1
gene UNIPROT MMRN1
disease MESH inflammation

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