Chronological View of Peak and Diphasic Dyskinesia, Wearing Off and Freezing of Gait in Parkinson’s Disease.

Chronological View of Peak and Diphasic Dyskinesia, Wearing Off and Freezing of Gait in Parkinson’s Disease.

Publication date: Sep 04, 2019

Dyskinesia, wearing off (WO) and freezing of gait (FOG) are troublesome complications degrading quality of life in the course of Parkinson’s disease (PD).

This study evaluated the gross chronological trend of 4 motor complications – peak dose dyskinesia (PDSK), diphasic dyskinesia (DDSK), WO and FOG in a large PD population with stratification by age at disease onset according to the PD duration.

The motor complications of 1212 Korean PD patients were analyzed using Kaplan-Meier curves and Cox proportional hazards models.

PDSK and WO appeared first as motor complications and showed accelerated development around the 5 year-PD-duration, while DDSK showed a rather constant development over time and FOG developed around the 10 year-disease duration at an accelerated rate (p 

Motor complications developed with a distinguishing inclination over the PD duration. This study provides insight into the chronological trend of motor complications in PD at a glance.

Kim, Y.E., Jeon, B., Yun, J.Y., Yang, H.J., and Kim, H.J. Chronological View of Peak and Diphasic Dyskinesia, Wearing Off and Freezing of Gait in Parkinson’s Disease. 22238. 2019 J Parkinsons Dis.

Concepts Keywords
Dyskinesia Dyskinesia
Gait Psychiatric diagnosis
Inclination RTT
Parkinson Geriatrics
Peak Nervous system
Proportional Hazards Models Medicine
Neurological disorders
Organ systems
Parkinson’s disease

Semantics

Type Source Name
disease MESH development
gene UNIPROT CPOX
gene UNIPROT LARGE1
disease MESH complications
disease MESH Gait
disease MESH Dyskinesia

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *