Downregulated lncRNA-SNHG1 enhances autophagy and prevents cell death through the miR-221/222 /p27/mTOR pathway in Parkinson’s disease.

Downregulated lncRNA-SNHG1 enhances autophagy and prevents cell death through the miR-221/222 /p27/mTOR pathway in Parkinson’s disease.

Publication date: Sep 06, 2019

Autophagy has been shown to be critically associated with the central mechanisms underlying Parkinson’s disease (PD), while the mechanisms contributing to the imbalance of autophagy remain unclear. Small nucleolar RNA host gene 1 (SNHG1), a well-studied long noncoding RNA, has been reported to be significantly increased in PD. The potential biological functions of SNHG1 in the regulation of neuronal autophagy and cell death in PD, however, have not yet been completely elucidated. In this study, we examined the existence of regulatory networks involving SNHG1, the miR-221/222 cluster and the cyclin-dependent kinase inhibitor 1B (CDKN1B/p27)/mammalian target of rapamycin (mTOR) signaling pathway in PD. We observed that SNHG1 expression was gradually upregulated in PD cellular and animal models. Furthermore, silencing SNHG1 promoted autophagy and prevented MPP-induced cell death, similar to the overexpression of the miR-221/222 cluster. Mechanistically, SNHG1 competitively binds to the miR-221/222 cluster and indirectly regulates the expression of p27/mTOR. In conclusion, these results demonstrated that downregulation of SNHG1 attenuated MPP-induced decreases in LC3-II (an autophagic marker) levels and cytotoxicity through the miR-221/222/p27/mTOR pathway, suggesting that SNHG1 may be a therapeutic target for neuroprotection and disease treatment in PD.

Qian, C., Ye, Y., Mao, H., Yao, L., Sun, X., Wang, B., Zhang, H., Xie, L., Zhang, H., Zhang, Y., Zhang, S., and He, X. Downregulated lncRNA-SNHG1 enhances autophagy and prevents cell death through the miR-221/222 /p27/mTOR pathway in Parkinson’s disease. 22231. 2019 Exp Cell Res.

Concepts Keywords
Autophagic Existence regulatory networks
Autophagy Branches of biology
CDKN1B Signal transduction
Cytotoxicity MTOR
Downregulation Autophagy
LncRNA CDKN1B
Long Noncoding RNA
MPP
MTOR
Neuroprotection
Parkinson
Rapamycin
Regulates Expression
Regulatory Networks

Semantics

Type Source Name
gene UNIPROT MPZ
gene UNIPROT CDKN1B
gene UNIPROT MTOR
gene UNIPROT TMED7
gene UNIPROT IFI27
gene UNIPROT MLXIP
gene UNIPROT MYLIP
gene UNIPROT MARCH8

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