Generation of Biological Samples Positive to Hydromorphone for Anti-doping Control

Generation of Biological Samples Positive to Hydromorphone for Anti-doping Control

Publication date: Sep 09, 2019

Background: Hydromorphone (HM) is a semi-synthetic derivative of morphine used for pain control. Like other opiates, due to its high potential of abuse HM is included on the World Anti-Doping Agency (WADA) list of prohibited substances. Hypothesis: The oral administration of hydromorphone hydrochloride in healthy subjects allows generating detectable concentrations of the drug in urine. Positive urine samples will enable to identify analytical strategies for doping control. Objectives: Primary objective: To measure the concentrations of hydromorphone in urine for anti-doping control samples. Secondary objective: To identify metabolites and precursors of hydromorphone in urine. To assess safety and tolerability of the drug used. Methods: Phase I, open, non-randomized clinical trial, with a treatment condition (hydromorphone) administered orally to 2 subjects.

Concepts Keywords
Alcohol Allergy idiosyncrasy hypersensitivity
Alcoholism Pain
Allergy Suggestive gastrointestinal irritation
Assay Acute abdominal pain
Asthma Diseases
Blood HIV
BMI Psychiatric disorders alcoholism
Buprenorphine Major surgery
Cardiovascular Opioids
Chronic Diseases Psychoactive drugs
Clinical Trial Euphoriants
Cola RTT
Cross Morphinans
Derivative Ketones
Doping Phenols
Drug Abuse Hydromorphone
ECG Morphine
Endocrine Clinical trial
Epilepsy Heroin
Epileptic Seizures
Excipients
Excretion
Gastrointestinal
Gastrointestinal Tract
Hematological
Hepatic
Hepatitis
HIV
Hydrochloride
Hydromorphone
Hypersensitivity
Immunoassay
Informed Consent
Liver
MAOIs
Metabolism
Monoamine Oxidase Inhibitors
Morphine
Neurological
Opiates
Opioids
Pain
Pentazocine
Physical Examination
Psychiatric Disorders
Psychoactive Drugs
Randomized Clinical Trial
Renal
Renal Disorder
Respiratory Failure
Serology
Stimulant
Stricture
Tolerability
Urine
WADA
Xanthines

Semantics

Type Source Name
drug DRUGBANK Hydromorphone
drug DRUGBANK Morphine
gene UNIPROT NR4A3
disease MESH allergy
disease DOID allergy
disease MESH stricture
disease MESH respiratory failure
disease DOID respiratory failure
disease MESH asthma
disease DOID asthma
pathway BSID Asthma
disease MESH renal
pathway BSID Metabolism
disease MESH alcoholism
disease DOID alcoholism
pathway BSID Alcoholism
disease MESH drug abuse
disease MESH chronic diseases
disease MESH epileptic seizures
disease MESH epilepsy
disease DOID epilepsy
drug DRUGBANK Buprenorphine
drug DRUGBANK Nalbuphine
drug DRUGBANK Pentazocine
disease MESH Smokers
drug DRUGBANK Ethanol
disease MESH men
disease MESH hepatitis B
disease DOID hepatitis B
pathway BSID Hepatitis B
gene UNIPROT NR4A2
gene UNIPROT ALG3
gene UNIPROT CCL18
gene UNIPROT CUL9

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