Reduced urinary opioid levels from pain management patients associated with marijuana use.

Reduced urinary opioid levels from pain management patients associated with marijuana use.

Publication date: Sep 09, 2019

Aim: Marijuana use has been postulated to modulate opioid use, dependence and withdrawal. Broad target drug testing results provide a unique perspective to identify any potential interaction between marijuana use and opioid use. Materials & methods: Using a dataset of approximately 800,000 urine drug test results collected from pain management patients of a time from of multiple years, creatinine corrected opioid levels were evaluated to determine if the presence of the primary marijuana marker 11-nor-carboxy-tetrahydrocannabinol (THC-COOH) was associated with statistical differences in excreted opioid concentrations. Results & conclusion: For each of the opioids investigated (codeine, morphine, hydrocodone, hydromorphone, oxycodone, oxymorphone, fentanyl and buprenorphine), marijuana use was associated with statistically significant lower urinary opiate levels than in samples without indicators of marijuana use.

Goggin, M.M., Shahriar, B.J., Stead, A., and Janis, G.C. Reduced urinary opioid levels from pain management patients associated with marijuana use. 03988. 2019 Pain Manag.

Concepts Keywords
Aim Pain management
Buprenorphine Pain management
Codeine Opioids
Creatinine Organic compounds
Drug Test RTT
Fentanyl Morphinans
Hydrocodone Euphoriants
Hydromorphone Phenols
Marijuana Opiates
Morphine Oxycodone
Opiate Oxymorphone
Opioid Hydromorphone
Opioids Morphine
Oxycodone Pain management
Oxymorphone
Pain Management
Urine

Semantics

Type Source Name
drug DRUGBANK Buprenorphine
drug DRUGBANK Fentanyl
drug DRUGBANK Oxymorphone
drug DRUGBANK Oxycodone
drug DRUGBANK Hydromorphone
drug DRUGBANK Hydrocodone
drug DRUGBANK Morphine
drug DRUGBANK Codeine
drug DRUGBANK Dronabinol
drug DRUGBANK Medical Cannabis
drug DRUGBANK Creatinine
gene UNIPROT DNMT1
gene UNIPROT CD69
disease MESH marijuana use

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