Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring.

Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring.

Publication date: Sep 06, 2019

In retrospective studies, the percentage of melanoma patients developing a second primary melanoma (SPM) ranges between 2% and 20%. Scarce evidence exists on the usefulness of total body photography (TBP) and digital dermatoscopic documentation (DDD) for detecting SPM.

The primary aim was to quantify the risk and investigate the time of occurrence of SPM. Secondary aims were to identify risk factors for SPM and to assess the usefulness of TBP and DDD for SPM detection.

This prospective cohort included patients with recently diagnosed melanoma that underwent sequential clinical and dermatoscopic examinations for up to 5 years. Life table analysis and Kaplan-Meier survival analysis were performed. Multivariate Cox-models were constructed to identify factors affecting the outcome.

Of 977 patients, 46 (4.7%) developed a SPM. Life table analysis revealed a 5-year cumulative risk of 8.0% for SPM. High nevus count, fair phototype and occupational sun exposure were potent predictors of SPM. Of all new melanomas, 17.3% were diagnosed by clinical and dermatoscopic examination, 48.1% by TBP and 34.6% by DDD.

In this cohort, melanoma patients were at 8% risk to develop a SPM within 5 years. TBP and DDD significantly contributed to the early detection of SPM.

Lallas, A., Apalla, Z., Kyrgidis, A., Papageorgiou, C., , Boukovinas, Bobos, M., Efthimiopoulos, G., Nikolaidou, C., Moutsoudis, A., Gkentsidi, T., Lallas, K., Lazaridou, E., Sotiriou, E., Vakirlis, E., and Ioannides, D. Second primary melanomas in a cohort of 977 melanoma patients within the first 5 years of monitoring. 24056. 2019 J Am Acad Dermatol.

Concepts Keywords
Cohort SPM melanomas
Digital RTT
Melanoma Cancer
Melanomas Melanoma
Nevus
Photography
Phototype
TBP

Semantics

Type Source Name
disease MESH nevus
gene UNIPROT CPOX
disease MESH risk factors
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT TBP
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanomas

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *