Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy -The HOPES Trial

Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy -The HOPES Trial

Publication date: Sep 12, 2019

A double-blind, randomized, placebo-controlled, single-center, 12-month phase 2 study designed to assess the safety and efficacy of VM202 as a replacement for opioid analgesics in opioid-tolerant subjects with painful diabetic peripheral neuropathy (DPN).

Concepts Keywords
Acupuncture TENS
Alcohol Abuse Immunosuppression
ALT Acupuncture
Amitriptyline Chemotherapy
Amphetamines Birth control
Amputation Amputation
Analgesic Radiation therapy
Analgesics Stroke
Antibodies History diabetes
Antibody Active Hepatitis
Antidepressants Significant anticipated diabetes
Antiepileptics Uncontrolled hypertension
Antigen Diabetic complications
Articular Active infection
AST Myopathy
Basal HIV
Benzodiazepines Condition diabetes
Birth Control Disease rheumatoid arthritis
Blood Myocardial infarction
BMI Psychiatric disorder
Capsaicin Additional pain syndrome
Carbamazepine Peripheral neuropathy
Carcinoma Symptoms diabetes
Chemotherapy Organ systems
Cocaine RTT
Colon Psychoactive drugs
Colonoscopy Medical specialties
Cymbalta Duloxetine
Diabetes Peripheral neuropathy
Diabetic Gabapentin
Diastolic Pregabalin
Double Blind Pain
Duloxetine Diabetes
Fiber Benzodiazepine
Gabapentin Anticonvulsant
HBsAg Radiation
HCV ISDN
Hemoglobin Antibodies
Hemoglobin A1c Chemotherapy
HIV
HTLV
Hypertension
IgG
IgM
Immunosuppression
Immunosuppressive Drugs
Infection
Informed Consent
Inhibitor
Insulin
Investigational Drug
ISDN
Local Anesthetic
Lyrica
Michigan
Microliter
Milligram
MmHg
Morphine
Muscle Relaxants
Myocardial Infarction
Myopathy
Neoplasm
Neurological Disorder
Neurontin
Neuropathy
Ophthalmologic
Ophthalmological
Opioid
Opioids
Pain
Peripheral Nervous System
Peripheral Neuropathy
Physical Examination
Placebo
Platelet
Polyneuropathy
Pregabalin
Pregnancy Test
Psychiatric Disorder
Radiation Therapy
Rating Scale
Retinopathy
Rheumatoid Arthritis
Skeletal Muscle
Squamous Carcinoma
Steroids
Syndrome
Systolic Blood Pressure
TENS
Urine
Valproic Acid
VEGF
Venlafaxine
WBC

Semantics

Type Source Name
gene UNIPROT ALG3
gene UNIPROT NR4A2
drug DRUGBANK Cocaine
disease MESH alcohol abuse
disease DOID alcohol abuse
disease MESH diabetic complications
gene UNIPROT VEGFA
gene UNIPROT PTGS2
gene UNIPROT PTGS1
drug DRUGBANK Vigabatrin
drug DRUGBANK Carbamazepine
drug DRUGBANK Valproic Acid
drug DRUGBANK Venlafaxine
drug DRUGBANK Amitriptyline
drug DRUGBANK Isosorbide dinitrate
drug DRUGBANK Capsaicin
gene UNIPROT EHD1
disease DOID colon cancer
disease MESH colon cancer
disease MESH recurrence
pathway BSID Basal cell carcinoma
disease DOID basal cell carcinoma
disease MESH basal cell carcinoma
disease DOID malignant neoplasm
disease MESH malignant neoplasm
gene UNIPROT DBP
gene UNIPROT HSD17B4
gene UNIPROT GC
gene UNIPROT SELENBP1
gene UNIPROT SHBG
disease DOID hypertension
disease MESH hypertension
gene UNIPROT LAT2
gene UNIPROT SLC17A5
disease DOID myocardial infarction
disease MESH myocardial infarction
disease DOID Stroke
disease MESH Stroke
pathway BSID Hepatitis C
disease DOID Hepatitis C
disease MESH Hepatitis C
drug DRUGBANK Hepatitis B Vaccine (Recombinant)
pathway BSID Hepatitis B
disease DOID Hepatitis B
disease MESH Hepatitis B
pathway BSID Rheumatoid arthritis
disease DOID rheumatoid arthritis
disease MESH rheumatoid arthritis
disease MESH infection
disease DOID Myopathy
disease MESH Myopathy
disease MESH neurological disorder
disease DOID syndrome
disease MESH syndrome
disease DOID polyneuropathy
disease MESH polyneuropathy
drug DRUGBANK Duloxetine
drug DRUGBANK Pregabalin
drug DRUGBANK Gabapentin
disease MESH Diagnosis
pathway BSID Release
gene UNIPROT MMP12
gene UNIPROT MME
drug DRUGBANK Morphine
gene UNIPROT INS
gene UNIPROT RENBP
drug DRUGBANK Nadide
disease DOID Peripheral Neuropathy
disease DOID Peripheral Neuropathy
disease MESH Peripheral Neuropathy

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *