Cancer biology as revealed by the research autopsy.

Cancer biology as revealed by the research autopsy.

Publication date: Sep 13, 2019

A research autopsy is a post-mortem medical procedure performed on a deceased individual with the primary goal of collecting tissue to support basic and translational research. This approach has increasingly been used to investigate the pathophysiological mechanisms of cancer evolution, metastasis and treatment resistance. In this Review, we discuss the rationale for the use of research autopsies in cancer research and provide an evidence-based discussion of the quality of post-mortem tissues compared with other types of biospecimens. We also discuss the advantages of using post-mortem tissues over other types of biospecimens, including the large amounts of tissue that can be obtained and the extent of multiregion sampling that is achievable, which is not otherwise possible in living patients. We highlight how the research autopsy has supported the identification of the clonal origins and modes of spread among metastases, the extent that selective pressures imposed by treatments cause bottlenecks leading to parallel and convergent tumour evolution, and the creation of rare tissue banks and patient-derived model systems. Finally, we comment on the future of the research autopsy as an integral component of precision medicine strategies.

Iacobuzio-Donahue, C.A., Michael, C., Baez, P., Kappagantula, R., Hooper, J.E., and Hollman, T.J. Cancer biology as revealed by the research autopsy. 05417. 2019 Nat Rev Cancer.

Concepts Keywords
Autopsies Metastases
Autopsy Tumour
Clonal Branches of biology
Evolution Forensic pathology
Integral Anatomical pathology
Metastases Autopsy
Metastasis Death
Pathophysiological Medicine
Post Mortem
Tumour

Semantics

Type Source Name
gene UNIPROT LARGE1
disease MESH metastasis
gene UNIPROT SLC35G1
gene UNIPROT DESI1
disease DOID Cancer
disease MESH Cancer

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