Unraveling susceptibility to multiple sclerosis

Unraveling susceptibility to multiple sclerosis

Publication date: Sep 29, 2019

Newly identified genetic variants highlight adaptive and innate immune response dysregulation.

Multiple sclerosis (MS) affects over 2.3 million people worldwide (1, 2). This autoimmune disease of the central nervous system (CNS) is a leading cause of nontraumatic disability in young and middleaged adults, disproportionately affecting women and those of northern European ancestry (3). MS pathogenesis is multifactorial, with prominent genetic and environmental risk components. However, the events mediating onset continue to elude researchers. On page 1417 of this issue, Patsopoulos et al. (4) identified 232 autosomal variants and the first X chromosome variant associated with MS susceptibility. Additionally, Cotsapas et al. (5) discovered five independent autosomal risk variants. These studies add resolution to the known function of adaptive immune responses and suggest a prominent role for dysregulation in multicellular innate immune processes in the narrative of MS susceptibility.

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Concepts Keywords
Accrete Http
Acti Natural killer cell
Allele Sjögren syndrome
Amino Acid Autoimmunity
Ant Major histocompatibility complex
Antigen Microglia
Antigens Glycoproteins
Astrocytes Glial cells
Autoimmune Medicine
Autopsy Immune system
Autosomal Branches of biology
Axons Medical specialties
Bioinformatic Disk gas
Blood
Blood Brain Barrier
Caucasians
Central Nervous System
Chromosome
Cleveland
Cohort
Cortex
Cortical
Demyelination
Disability
Doppler
Etiology
Euclid Avenue
Fragmentation
Frequency
Fugger
Genetic
Genetic Variation
Genome
Giant Planet
Heritability
Heritable
Hispanic
Histocompatibility
HLA
Icarus
Immune Cells
Incidence
Inflammation
Inflammatory Events
Ing
Innate Immunity
Integral
Interac
Intergenic Regions
Interplay
Jupiter
Jurgenson
Lancet
Leukocyte
Loci
Lymphocytes
Macrophages
Major Histocompatibility Complex
Marooning
Mecha
Megabase
MHC
Microglia
Mit
Molecule
Mono
Monocytes
Multicellular
Multiple Sclerosis
Myelin
Natural Killer
Nature
Nerve Impulses
Neurology
Neurons
Oligodendrocytes
Orbit
Orbital Speed
Pathogenesis
Phagocytes
Planet
Planet Formation
Pluripotent
Polymorphic
Pos
Prefrontal
Prefrontal Cortex
Protoplanetary Disk
Protostellar
Red Dwarf
Risk Factor
Sex Chromosomes
SPIE
Star
Statistical Significance
Velocity Shear
Western Reserve

Semantics

Type Source Name
gene UNIPROT AAAS
gene UNIPROT SULT1A3
disease MESH Mult
gene UNIPROT SCN8A
gene UNIPROT EXOG
disease MESH multi
disease MESH development
gene UNIPROT FYB1
disease MESH men
gene UNIPROT TALDO1
gene UNIPROT LRSAM1
gene UNIPROT GOPC
gene UNIPROT PLXNA3
gene UNIPROT FRZB
gene UNIPROT NR4A3
gene UNIPROT SGSM3
gene UNIPROT TNFRSF10B
gene UNIPROT RBM45
disease MESH risk factor
disease MESH demyelination
disease MESH inflammation
gene UNIPROT MAGEE1
gene UNIPROT MARK1
drug DRUGBANK Tegafur
gene UNIPROT PROC
gene UNIPROT UBXN11
drug DRUGBANK Serine
gene UNIPROT CCAR1
gene UNIPROT HINT1
gene UNIPROT GUCY2C
gene UNIPROT STAR
gene UNIPROT GAST
gene UNIPROT PAGR1
gene UNIPROT LARGE1
gene UNIPROT IK
gene UNIPROT ABRA
disease DOID autoimmune disease
disease MESH autoimmune disease
disease DOID multiple sclerosis
disease MESH multiple sclerosis

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