Publication date: Oct 01, 2019
Human iPSCs provide a virtually unlimited resource of patient-specific and healthy glial and neural cells for use in toxicological screening, biomedical research and drug evaluation.
This is achievable by culturing cells under fully-defined, xeno-free conditions while expanding stem cells, then differentiating them into high-purity neuronal cell types, and finally maintaining them long-term in vitro.
Researchers can generate pure cell populations for use in disease modeling and drug discovery using human iPSC-derived neural stem cells (NSCs), astrocytes, neurons and culture reagents such as those offered by Axol.
Cultures such as this could be used to determine the direct effect of compounds on these specific cells, or elucidate the mechanisms that occur in neuronal development or precede the onset of neurodegenerative conditions.
NSCs give rise to cell types that are more advanced, for example oligodendrocytes, astrocytes and neurons that connect to form networks in the spinal cord and brain.
Astrocytes are glial cells that support both the trophic and metabolic development of neurons.
Axol can provide iPSC-Derived Cerebral Cortical Neurons and Neural Stem Cells from patients with Huntington’s and Alzheimer’s disease as well as from controls.
The Xeno-Free Neural Cell Culture System from Axol is also available and has been optimized for long-term culture of pure neuronal cell populations.
Axol produces high quality human cell products and critical reagents such as media and growth supplements.
Our in-house R&D team works hard to improve on existing media and reagents as well as innovate new products for human cell culture.
We also supply a growing range of human primary cells; making Axol your first port of call for your human cell culture needs.
|disease||DOID||attention deficit hyperactivity disorder|
|disease||MESH||attention deficit hyperactivity disorder|
|disease||DOID||amyotrophic lateral sclerosis|
|disease||MESH||amyotrophic lateral sclerosis|