hiPSC-Derived Neural and Glial Cells for Disease Modelling and Drug Discovery

hiPSC-Derived Neural and Glial Cells for Disease Modelling and Drug Discovery

Publication date: Oct 01, 2019

Human iPSCs provide a virtually unlimited resource of patient-specific and healthy glial and neural cells for use in toxicological screening, biomedical research and drug evaluation.

This is achievable by culturing cells under fully-defined, xeno-free conditions while expanding stem cells, then differentiating them into high-purity neuronal cell types, and finally maintaining them long-term in vitro.

Researchers can generate pure cell populations for use in disease modeling and drug discovery using human iPSC-derived neural stem cells (NSCs), astrocytes, neurons and culture reagents such as those offered by Axol.

Cultures such as this could be used to determine the direct effect of compounds on these specific cells, or elucidate the mechanisms that occur in neuronal development or precede the onset of neurodegenerative conditions.

NSCs give rise to cell types that are more advanced, for example oligodendrocytes, astrocytes and neurons that connect to form networks in the spinal cord and brain.

Astrocytes are glial cells that support both the trophic and metabolic development of neurons.

Axol can provide iPSC-Derived Cerebral Cortical Neurons and Neural Stem Cells from patients with Huntington’s and Alzheimer’s disease as well as from controls.

The Xeno-Free Neural Cell Culture System from Axol is also available and has been optimized for long-term culture of pure neuronal cell populations.

Axol produces high quality human cell products and critical reagents such as media and growth supplements.

Our in-house R&D team works hard to improve on existing media and reagents as well as innovate new products for human cell culture.

We also supply a growing range of human primary cells; making Axol your first port of call for your human cell culture needs.

Concepts Keywords
Acetylcholine Regenerative medicine
Addiction Stem cells
ADHD Neuroscience
ALS Astrocyte
Amyotrophic Lateral Sclerosis Neuron
Astrocyte Neuronal lineage marker
Astrocytes Neural stem cell
Biomedical Developmental biology
Blood Induced stem cells
Brain Biotechnology
Cas9 Stem cells
Central Nervous System Glial cells
Cortical Branches of biology
CRISPR Media reagents
Dopamine Media coating reagents
Dopaminergic Lines disease
Drug Addiction
Electrical Conductivity
Epic
Epilepsy
Episomal
Excitatory
Fibroblasts
GABA
Gamma Aminobutyric Acid
Gene
Genetic
Glial
Glutamate
Isogenic
KLF4
Memory
Memory Formation
Midbrain
MYC
Myelination
Neurodegenerative
Neurological
Neurological Disorders
Neuron
Neuronal Migration
Neurons
Neuroscience
Nobel Prize
OCT4
Oligodendrocytes
Phenotype
Pluripotency
Pluripotent
Port
Psychosis
Regenerative Medicine
Sendai
Serotonin
SOX2
Spinal Cord
Stem Cells
Stress
Substantia Nigra
Synaptic
Synaptic Junctions
Synaptogenesis
Toxicological
Trophic
Vectors
Ventral
Viral Transduction
Vivo

Semantics

Type Source Name
disease DOID attention deficit hyperactivity disorder
disease MESH attention deficit hyperactivity disorder
drug DRUGBANK Meclofenamic acid
gene UNIPROT ELK3
gene UNIPROT CHL1
gene UNIPROT SLC6A2
gene UNIPROT EPHB1
gene UNIPROT RXFP2
gene UNIPROT KIT
disease MESH drug addiction
disease MESH psychosis
disease MESH syndromes
drug DRUGBANK gamma-Aminobutyric acid
drug DRUGBANK Serotonin
drug DRUGBANK Dopamine
drug DRUGBANK Acetylcholine
gene UNIPROT KLF4
gene UNIPROT IGFALS
disease MESH epilepsy
disease DOID epilepsy
gene UNIPROT SOX2
gene UNIPROT POU5F1
drug DRUGBANK Myricetin
gene UNIPROT MYC
disease DOID amyotrophic lateral sclerosis
disease MESH amyotrophic lateral sclerosis
disease MESH neurological disorders
disease MESH development

Original Article

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