Publication date: Oct 01, 2019
This post was originally published on this site Different types of apathy – a common psychiatric symptom of Huntington’s disease – are associated with specific alterations in the brain’s white matter in patients at different stages of the disease, a study finds. Some studies have attempted to investigate the correlation between apathy symptoms and white matter brain lesions visible by diffusion tensor imaging (DTI), a technique that measures the diffusion of water molecules in the brain to assess white matter integrity. -However, such studies have yielded inconsistent results, perhaps due to the great variability among HD [Huntington’s disease] individuals in the degree and evolution of apathy symptoms. To learn more, researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Neuroscience Institute of the University of Barcelona (UBNeuro), both in Spain, set out to look for possible associations between alterations in the white matter of Huntington’s patients at varying disease stages and different types of apathy. -Our goal was to study apathy as a multidimensional syndrome and explore, for the first time, the relationship between different subtypes of apathy and white matter connectivity in Huntington’s disease,” Estela CcE0mara, lead author of the study, said in a press release. DTI also revealed that individual differences in the integrity of white matter nerve tracts in specific regions of the brain could explain, at least to some degree, the different severity levels of the various types of apathy seen in those participating in the study.
- White matter cortico-striatal tracts predict apathy subtypes in Huntington’s disease.
- Apathy as an indicator of progression in Huntington’s disease
- A Touchscreen Motivation Assessment Evaluated in Huntington’s Disease Patients and R6/1 Model Mice.