Apathy Linked to Changes in Brain White Matter at Different Huntington’s Stages, Study Finds

Apathy Linked to Changes in Brain White Matter at Different Huntington’s Stages, Study Finds

Publication date: Oct 01, 2019

This post was originally published on this site Different types of apathy – a common psychiatric symptom of Huntington’s disease – are associated with specific alterations in the brain’s white matter in patients at different stages of the disease, a study finds. Some studies have attempted to investigate the correlation between apathy symptoms and white matter brain lesions visible by diffusion tensor imaging (DTI), a technique that measures the diffusion of water molecules in the brain to assess white matter integrity. -However, such studies have yielded inconsistent results, perhaps due to the great variability among HD [Huntington’s disease] individuals in the degree and evolution of apathy symptoms. To learn more, researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Neuroscience Institute of the University of Barcelona (UBNeuro), both in Spain, set out to look for possible associations between alterations in the white matter of Huntington’s patients at varying disease stages and different types of apathy. -Our goal was to study apathy as a multidimensional syndrome and explore, for the first time, the relationship between different subtypes of apathy and white matter connectivity in Huntington’s disease,” Estela CcE0mara, lead author of the study, said in a press release. DTI also revealed that individual differences in the integrity of white matter nerve tracts in specific regions of the brain could explain, at least to some degree, the different severity levels of the various types of apathy seen in those participating in the study.

Concepts Keywords
Apathy Neuroscience
Asymptomatic Brain damage
Axons Diffusion MRI
Barcelona White matter
Bear Syndrome
Biomarker Narcissism
Brain Emotions
Cognitive Apathy
Correlation Abnormal psychology
Differential Diagnosis Neurotrauma
Diffusion Neuroscience
Diffusion Tensor Imaging Nervous system
DTI Organ systems
Evolution Genetic neurodegenerative disorder
Genetic Apathy multidimensional syndrome
Huntington
Lille
Microstructure
Myelinated
Nerve
Neurodegeneration
Neurodegenerative Disorder
Neuroimaging
Neuropsychiatric
Pharmacological
Progressive
Push Start
Spain
Symptom
Syndrome
The Automatic
White
White Matter

Semantics

Type Source Name
disease MESH diagnosis
disease MESH Problem Behavior
pathway BSID Release
disease DOID syndrome
disease MESH syndrome
gene UNIPROT SET
gene UNIPROT RXFP2
drug DRUGBANK Water
disease MESH disease progression
disease MESH neurodegenerative disorder
gene UNIPROT SLC35G1
gene UNIPROT DESI1
disease MESH Apathy

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