NFIA Protein Essential to Astrocytes, Brain Cells Active in Spinal Cord Repair and Remyelination, Study Suggests

NFIA Protein Essential to Astrocytes, Brain Cells Active in Spinal Cord Repair and Remyelination, Study Suggests

Publication date: Oct 02, 2019

A protein known as nuclear factor I-A (NFIA) is key for spinal cord repair and timely remyelination by astrocytes – the most abundant cells in the brain and first responders to sites of injury, findings in a mouse model of multiple sclerosis (MS) suggest. In brain lesions, NFIA is also essential to generating reactive astrocytes, the state these cells assume when responding either to acute injury or to neurodegeneration due to chronic disease. When they eliminated NFIA in mice astrocytes, they observed that, in the spinal cord, reactive astrocytes were generated and migrated toward the injury, but did not repair the damaged blood-brain barrier – a barrier shielding the brain from peripheral blood circulation. -These findings suggest that NFIA’s function in reactive astrocytes is dependent upon the type of injury and brain region in which the injury occurs. Results also showed no thrombospondin 4 (THBS4), key for the generation of reactive astrocytes, in the SVZ and other brain regions of mice lacking NFIA. -Although our study was conducted in mice and more research is needed, we think our findings may reflect what occurs in people, as NFIA also is abundantly present in reactive astrocytes in both pediatric and adult neurological injuries,” Deneen said.

Concepts Keywords
Astrocyte Neurosurgery
Astrocytes Astrogliosis
Baylor Glial scar
Blood Spinal cord
Blood Brain Barrier Human brain
Blood Circulation Subventricular zone
Brain Central nervous system
Central Nervous System Astrocyte
Cerebral Cortex Developmental neuroscience
Chronic Disease Glial cells
Gene Nervous system
Glioma Organ systems
Ischemic Stroke Branches of biology
Multiple Sclerosis Neurosurgery
Myelin Neonatal ischemic stroke
Neonatal Due chronic disease
Nerve MS
Neurodegeneration Toacute injury
Neurodegenerative Diseases
Neurological
Neurological Diseases
Neurosurgery
Oligodendrocytes
Pediatric
PhD
Protein
Reservoir
Spectrum
Spinal Cord
Subventricular Zone
Thrombospondin
Transcription Factor
White Matter
WMI

Semantics

Type Source Name
gene UNIPROT SET
pathway BSID Neurodegenerative Diseases
disease MESH neurodegenerative diseases
disease DOID dish
gene UNIPROT LAT2
gene UNIPROT THBS4
gene UNIPROT HINT1
gene UNIPROT BTG3
gene UNIPROT PDC
pathway BSID Glioma
disease MESH glioma
pathway BSID Gene Expression
disease MESH chronic disease
gene UNIPROT NFIA
disease MESH multiple sclerosis
disease DOID multiple sclerosis

Original Article

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