Profiling Inflammatory Markers in Cerebrospinal Fluid of Importance in Active MS, Case Study Finds

Profiling Inflammatory Markers in Cerebrospinal Fluid of Importance in Active MS, Case Study Finds

Publication date: Oct 02, 2019

Careful profiling of inflammatory markers in cerebrospinal fluid (CSF) of multiple sclerosis patients, coupled with standard exams and scans, helps in understanding disease evolution and treatment response, a case report suggests. It followed a relapsing-remitting multiple sclerosis (RRMS) patient whose inflammatory markers in the CSF remained high over time, and who responded poorly to several immunomodulatory treatments. The first CSF analysis found levels of 42 inflammatory molecules at least twice as high as those in a control group of 26 patients, including 14 people with other inflammatory neurological diseases. These results suggest that unusually high levels of inflammatory markers in the CSF -could remain stable or increase over time in patients with active multiple sclerosis,” the researchers wrote. -[W]e underline the usefulness of CSF assessment, combined with clinical and MRI follow-up, to identify the specific immune-inflammatory profile involved in the disease evolution of each MS patient. “

Concepts Keywords
Alemtuzumab MRI
Biomarker Magnetic resonance imaging
Biomarkers Multiple sclerosis biomarkers
Blood Cerebrospinal fluid
BMC Neurology Fluid-attenuated inversion recovery
Brain Biomarkers
Cerebrospinal Fluid Ventricular system
Contrast Agent Autoimmune diseases
Control Group Neurology
CXCL12 Medicine
Cyclophosphamide Medical specialties
Disability Organ systems
Evolution Multiple sclerosis
Fluid Active multiple sclerosis
Gadolinium Inflammatory molecules
Genzyme Active disease
Glatiramer Acetate Inflammatory pathways
High Time
IL10
IL6
Immunomodulatory
Interferon
Magnetic Resonance Imaging
Memory
MRI
Multiple Sclerosis
Natalizumab
Neurofilament
Neurological Diseases
NfL
Relapse
Spinal Cord
T2 Weighted
TNF
Tysabri

Semantics

Type Source Name
drug DRUGBANK Isoxaflutole
gene UNIPROT NEFL
gene UNIPROT IL10
gene UNIPROT IL6
gene UNIPROT TNFSF14
gene UNIPROT CXCL12
gene UNIPROT TNF
gene UNIPROT CXCL13
drug DRUGBANK Antithymocyte immunoglobulin (rabbit)
drug DRUGBANK Alemtuzumab
drug DRUGBANK Dimethyl fumarate
drug DRUGBANK Cyclophosphamide
gene UNIPROT TNFSF13
gene UNIPROT ANP32B
drug DRUGBANK Natalizumab
disease MESH relapses
drug DRUGBANK Acetate ion
drug DRUGBANK Glatiramer
drug DRUGBANK Gadolinium
gene UNIPROT CYREN
disease MESH diagnosis
disease DOID RRMS
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT CSF2

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