Multimodal characterization of the visual network in Huntington’s disease gene carriers.

Multimodal characterization of the visual network in Huntington’s disease gene carriers.

Publication date: Aug 28, 2019

A sensorimotor network structural phenotype predicted motor task performance in a previous study in Huntington’s disease (HD) gene carriers. We investigated in the visual network whether structure – function – behaviour relationship patterns, and the effects of the HD mutation, extended beyond the sensorimotor network.

We used multimodal visual network MRI structural measures (cortical thickness and white matter connectivity), plus visual evoked potentials and task performance (Map Search; Symbol Digit Modalities Test) in healthy controls and HD gene carriers.

Using principal component (PC) analysis, we identified a structure – function relationship common to both groups. PC scores differed between groups indicating white matter disorganization (higher RD, lower FA) and slower, and more disperse, VEP signal transmission (higher VEP P100 latency and lower VEP P100 amplitude) in HD than controls while task performance was similar.

HD may be associated with reduced white matter organization and efficient visual network function but normal task performance.

These findings indicate that structure – function relationships in the visual network, and the effects of the HD mutation, share some commonalities with those in the sensorimotor network. However, implications for task performance differ between the two networks suggesting the influence of network specific factors.

Gregory, S., Odish, O.F.F., , Mayer, Mills, J., Johnson, E.B., Scahill, R.I., Rothwell, J., Rees, G., Long, J.D., Tabrizi, S.J., Roos, R.A.C., and Orth, M. Multimodal characterization of the visual network in Huntington’s disease gene carriers. 06707. 2019 Clin Neurophysiol (130):11.

Concepts Keywords
Amplitude Visual network
Cortical Influence network
Evoked Potentials Characterization visual network
Huntington Multimodal visual network
Latency Carriers sensorimotor network
MRI Electroencephalography
Multimodal Evoked potential
Mutation Tractography
PC Sensorimotor
Phenotype MRI
Test
White Matter

Semantics

Type Source Name
gene UNIPROT TPX2
gene UNIPROT PMEL
gene UNIPROT SGSM3
gene UNIPROT CYREN
gene UNIPROT KCNK3
disease MESH visual

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