Protein associated with many diseases fully visualized for first time

Protein associated with many diseases fully visualized for first time

Publication date: Oct 02, 2019

Oregon Health & Science University research assistant Alanna McCarthy, B. S., and OHSU researcher Steven Mansoor, M. D., Ph. D., used cryoelectron microscopy to obtain the 3D structure of a protein receptor and observe its inner workings. They specifically studied the P2X7 receptor, a subtype of the ligand-gated ion channel P2X family that has been associated with inflammation, plaque buildup in arteries, cancer metastasis, neurological conditions and more. Mansoor and his team will further explore the roles that palmitoyl groups and the guanosine nucleotide play in P2X7 intra-cellular signaling, their potential impact on human health, and how they could be targeted to treat health conditions associated with the receptor. REFERENCE: Alanna E. McCarthy, Craig Yoshioka, Steven E. Mansoor, Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization, Cell, 11 a. m. ET Oct. 3, 2019, DOI: 10. 1016/j. cell. 2019. 09. 017, https:/ (19)31068-2 * 5/15/18 OHSU News Hub story, “OHSU one of three centers selected to study cells at atomic level,” https:/

Concepts Keywords
Arteries Imaging
Calcium Diseases
Cancer Branches of biology
Cardiovascular Cell biology
Cellular Membrane Neurochemistry
Cellular Signaling Cell signaling
Coronary Artery Disease Integral membrane proteins
Cryo Protein families
Cryoelectron Microscopy P2RX7
Desensitization Palmitoylation
Electrically Charged Signal transduction
Fatty Acid Ligand-gated ion channel
Guanosine Receptor
Howard Hughes
Inflammation
Ion Channels
Metastasis
Multiple Sclerosis
Neurological
Nucleotide
Oregon
Pacific Northwest
Palmitoyl
Palmitoylation
Receptor
Sodium

Semantics

Type Source Name
gene UNIPROT P2RX7
disease MESH inflammation
disease MESH coronary artery disease
disease DOID coronary artery disease
disease MESH cancer
disease DOID cancer
disease MESH multiple sclerosis
disease DOID multiple sclerosis
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Calcium
disease MESH metastasis
gene UNIPROT SIT1
drug DRUGBANK Hexadecanal
drug DRUGBANK Guanosine
gene UNIPROT IMPACT
gene UNIPROT LAT2
drug DRUGBANK Etodolac
gene UNIPROT DYNAP
gene UNIPROT PLXNA2
drug DRUGBANK Huperzine B
gene UNIPROT ELAVL2

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