Neural bases of Impulse Control Disorders in Parkinson’s disease: a systematic review and an ALE meta-analysis.

Neural bases of Impulse Control Disorders in Parkinson’s disease: a systematic review and an ALE meta-analysis.

Publication date: Oct 03, 2019

Impulse control disorders (ICD) occur in some patients affected by Parkinson’s disease (PD). Previous studies revealed an involvement of basal ganglia in ICD, but recent morphological, molecular and functional imaging studies showed that alterations of some extrastriatal regions contribute to development of ICD in PD, with mixed results. To identify the brain regions underlying ICD in PD, a systematic review of morphometric and functional studies was performed, complemented by an ALE meta-analysis of functional studies. The review of structural studies revealed no significant changes in any cortical and subcortical region in patients with ICD. The review of functional studies revealed increased activity in the Ventral Striatum and OrbitoFrontal Cortex and decreased activity in Anterior Cingulate Cortex (ACC). Clusters of hyperactivation in ventral striatum and of hypoactivation in ACC were confirmed by ALE meta-analysis. In conclusion, the present study strongly supported that ICD in PD are related to a dysfunction of limbic divisions of the striatum and of the prefrontal cortex and provided a neurofunctional basis for devising potential therapeutic interventions.

Santangelo, G., Raimo, S., Cropano, M., Vitale, C., Barone, P., and Trojano, L. Neural bases of Impulse Control Disorders in Parkinson’s disease: a systematic review and an ALE meta-analysis. 22529. 2019 Neurosci Biobehav Rev.

Concepts Keywords
ACC Disease
Basal Ganglia Dysfunction
Brain Brain
Cortical Cerebrum
Functional Imaging Basal ganglia
Impulse Striatum
Impulse Control Disorders Prefrontal cortex
Limbic Anterior cingulate cortex
Meta Analysis Orbitofrontal cortex
Morphological Cerebral cortex
Morphometric ALE
Parkinson
Prefrontal Cortex
Striatum
Ventral Striatum

Semantics

Type Source Name
disease MESH development
disease MESH Impulse Control Disorders

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