Publication date: Oct 07, 2019
Objectives : In present investigation, imiquimod (IMQ) was coupled to oleic acid (OLA; IMQ-OLA) to synthesize prodrug to reduce crystallinity that later amalgamated with oil-in-water (o/w) emulsion cream (IMQ-OLA cream) for the treatment of melanoma tumour. Methods and Results : The synthesis of IMQ-OLA prodrug was verified by FT-IR, HNMR and mass spectroscopy. The crystalline lattice of IMQ was transformed to somewhat amorphous structure in IMQ-OLA prodrug. IMQ-OLA cream retained 35.6% of IMQ within skin, significantly (P 0.05) at day 32 over 17-days period of treatment. IMQ-OLA cream followed the multiple mechanisms of cell death. Conclusion : IMQ-OLA cream warrants further in depth investigations for translating in to a clinically viable topical dermal product.
Sharma, A., Sharma, D., Baldi, A., Jyoti, K., Chandra, R., and Madan, J. Imiquimod-oleic acid prodrug loaded cream reduced drug crystallinity and induced indistinguishable cytotoxicity and apoptosis in mice melanoma tumour. 24385. 2019 J Microencapsul.
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