Imiquimod-oleic acid prodrug loaded cream reduced drug crystallinity and induced indistinguishable cytotoxicity and apoptosis in mice melanoma tumour.

Imiquimod-oleic acid prodrug loaded cream reduced drug crystallinity and induced indistinguishable cytotoxicity and apoptosis in mice melanoma tumour.

Publication date: Oct 07, 2019

Objectives : In present investigation, imiquimod (IMQ) was coupled to oleic acid (OLA; IMQ-OLA) to synthesize prodrug to reduce crystallinity that later amalgamated with oil-in-water (o/w) emulsion cream (IMQ-OLA cream) for the treatment of melanoma tumour. Methods and Results : The synthesis of IMQ-OLA prodrug was verified by FT-IR, HNMR and mass spectroscopy. The crystalline lattice of IMQ was transformed to somewhat amorphous structure in IMQ-OLA prodrug. IMQ-OLA cream retained 35.6% of IMQ within skin, significantly (P  0.05) at day 32 over 17-days period of treatment. IMQ-OLA cream followed the multiple mechanisms of cell death. Conclusion : IMQ-OLA cream warrants further in depth investigations for translating in to a clinically viable topical dermal product.

Sharma, A., Sharma, D., Baldi, A., Jyoti, K., Chandra, R., and Madan, J. Imiquimod-oleic acid prodrug loaded cream reduced drug crystallinity and induced indistinguishable cytotoxicity and apoptosis in mice melanoma tumour. 24385. 2019 J Microencapsul.

Concepts Keywords
Amorphous Apoptosis
Apoptosis Spectroscopy
Crystalline Lattice Ola
Crystallinity Oleic acid
Cytotoxicity DEPT
Emulsion Imiquimod
Imiquimod Antineoplastic drugs
Mass Spectroscopy Antivirals
Melanoma Organic compounds
Oil Melanoma
Oleic Acid RTT
Prodrug Clinical medicine
Topical Medicine
Tumour Melanoma
Topical dermal product
Crystallinity amalgamated oil

Semantics

Type Source Name
drug DRUGBANK Water
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
pathway BSID Apoptosis
drug DRUGBANK Oleic Acid
drug DRUGBANK Imiquimod

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