Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives.

Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives.

Publication date: Oct 06, 2019

Advances in transcriptome sequencing have revealed that the genome fraction largely encodes for thousands of non-coding RNAs. Long non-coding RNAs (lncRNAs), which are a class of non-protein-coding RNAs longer than approximately 200 nucleotides in length, are emerging as key epigenetic regulators of gene expression recently. Intensive studies have characterized their crucial roles in cutaneous biology and diseases. In this review, we address the promotive or suppressive effects of lncRNAs on cutaneous physiological processes. Then, we focus on the pathogenic role of dysfunctional lncRNAs in a variety of proliferative skin diseases. These evidences suggest that lncRNAs have indispensable roles in the processes of skin biology. Additionally, lncRNAs might be promising biomarkers and therapeutic targets for cutaneous disorders.

Tang, L., Liang, Y., Xie, H., Yang, X., and Zheng, G. Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives. 24386. 2019 Cell Prolif.

Concepts Keywords
Biomarkers HOXA11-AS1
Epigenetic Molecular genetics
Genome Long non-coding RNA
LncRNAs Life sciences
Nucleotides Branches of biology
Pathogenic Organic compounds
Protein Biotechnology
Sequencing RNA
Transcriptome Cutaneous squamous carcinoma
Crucial cutaneous diseases

Semantics

Type Source Name
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease DOID squamous cell carcinoma
disease MESH squamous cell carcinoma
pathway BSID Gene Expression
disease MESH skin diseases
disease DOID psoriasis
disease MESH psoriasis

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