Publication date: Oct 06, 2019
Genetic analysis of patients with familial Parkinson’s disease (PD) identified many causative genes. However, the majority of PD cases are sporadic, and the mechanisms of onset still remain unclear. Previously, we found that Midnolin (MIDN) is associated with PD in a Yamagata (Japan) cohort study and that MIDN regulates neurite outgrowth and Parkin expression in neuronal cells. In the present study, we aimed to replicate the genetic association between MIDN and PD in a large British population cohort.
In this replication study, we analyzed the copy number variations and single-nucleotide polymorphisms of the MIDN gene in a large British population on a case-control genome-wide association study dataset including 2,860 controls and 2,168 PD patients.
There was significant copy number loss in the MIDN gene with an odds ratio of 4.35 (P
Obara, Y., Sato, H., Nakayama, T., Kato, T., and Ishii, K. Midnolin is a confirmed genetic risk factor for Parkinson’s disease. 22532. 2019 Ann Clin Transl Neurol.
|Odds Ratio||Genetic variation|
|Single Nucleotide Polymorphisms|
- Association between nucleotide-binding oligomerization domain protein 2 (NOD2) gene polymorphisms and Parkinson’s disease (PD) susceptibility.
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- Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.