The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology.

The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology.

Publication date: Oct 07, 2019

Engineered proteins with enhanced or altered functionality, generated for example by mutation or domain fusion, are at the core of nearly all synthetic biology endeavors in the context of precision medicine, also known as personalized medicine. From designer receptors sensing elevated blood markers to effectors rerouting signaling pathways to synthetic transcription factors and the customized therapeutics they regulate, engineered proteins play a crucial role at every step of novel therapeutic approaches using synthetic biology. Here, recent developments in protein engineering aided by advances in directed evolution, de novo design, and machine learning are discussed. Building on clinical successes already achieved with chimeric antigen receptor (CAR-) T cells and other cell-based therapies, these developments are expected to further enhance the capabilities of mammalian synthetic biology in biomedical and other applications.

Bojar, D. and Fussenegger, M. The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology. 05531. 2019 Small.

Concepts Keywords
Biomedical Synthetic biology
Blood Biocybernetics
Chimeric Antigen Receptor Appropriate technology
Directed Evolution Emerging technologies
Engineering Biotechnology
Mutation Branches of biology
Personalized Medicine Articles
Precision Medicine Directed evolution
Receptors
Synthetic Biology
Transcription Factors

Semantics

Type Source Name
gene UNIPROT ARR3
gene UNIPROT CXADR
gene UNIPROT CASR
gene UNIPROT NR1I3
gene UNIPROT SPG7
gene UNIPROT PTPN5

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