U.S. Supreme Court rejects Acorda appeal in MS drug patent fight

U.S. Supreme Court rejects Acorda appeal in MS drug patent fight

Publication date: Oct 07, 2019

Publication date: Available online 5 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Ting Wang, Zhiyun Lian, Xi Wu, Yazhuo Kong, Dr Hongyu Zhou, Min WeiAbstractNeuromyelitis optica (NMO) is a disease characterised by severe relapses of optic neuritis and longitudinally extensive transverse myelitis and it has a strong female predilection. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph. Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Ano. .. Increased Levels of Endothelin-1 in Cerebrospinal Fluid Are a Marker of Poor Visual Recovery after Optic Neuritis in Multiple Sclerosis Patients. Conclusions: Severity and failure in the recovery from ON in MS patients may depend from vascular hypoperfusion of the optic nerve induced by high intrathecally produced ET-1, a potential prognostic marker of ON recovery in MS. The detection of CSF ET-1 levels may allow identifying groups of ON patients potentially benefitting from treatment with ET-1 antagonists (e. g., bosentan). PMID: 31583163 [PubMed] Efficacy of different rituximab therapeutic strategies in patients with neuromyelitis optica spectrum disorders Publication date: Available online 4 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Giovanni Novi, Francesca Bovis, Marco Capobianco, Jessica Frau, Giorgia Mataluni, Erica Curti, Luigi Zuliani, Paola Cavalla, Laura Brambilla, Pietro Annovazzi, Anna Maria Repice, Roberta Lanzillo, Sabrina Esposito, Luana Benedetti, Ilaria Maietta, Francesco Sica, Fabio Buttari, Simona Malucchi, Giuseppe Fenu, Doriana LandiAbstractObjectiveTo evaluate disease activity according to rituximab (RTX) induction and maintenance regimens in a multicenter real-life dataset of NMOSD patients. Methodsthis is an of multiple sclerosis and brain tumours: case report and review Publication date: Available online 4 October 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Andrii Sirko, Lyudmila Dzyak, Ekaterina Chekha, Tetiana Malysheva, Dmytro RomanukhaAbstractIn the present report, a review of the literature on the combination of multiple sclerosis and brain tumours is performed. Purpose of review Optic neuritis is an autoimmune optic neuropathy that has been associated with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and more recently antimyelin oligodendrocyte glycoprotein (anti-MOG)-positive disorder.

Concepts Keywords
Bovis Neurological disorders
Brain Tumours Organ systems
Cerebrospinal Fluid Autoimmune diseases
Cognitive Pain
Concurrent ProcessConclusion concurrent glioma
ET Autoimmune optic neuropathy
Etiopathogenetic Transverse myelitis
Frequency Multiple sclerosis treatment
Gender Multiple sclerosis
Giorgia Medical specialties
Glioma Rare diseases
Glycoprotein Neuromyelitis optica
Hypoperfusion Myelin oligodendrocyte glycoprotein
Intrathecally Optic neuritis
Lot Optic neuropathy
Magnetic Resonance Imaging Autoimmune optic neuropathy
Memory Magnetic resonance imaging
MOG MRI
MRI
Multiple Sclerosis
Neuritis
Neuromyelitis Optica
Neuropathic Pain
Oligodendrocyte
Opioid
Opioids
Optic Nerve
Optic Neuritis
Patent
PubMed
Rituximab
RTX
Sabrina
Spectrum
Supreme Court
Symptom
Temporal Lobe
Transverse Myelitis

Semantics

Type Source Name
disease MESH optic neuritis
disease MESH relapses
drug DRUGBANK Dalfampridine
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease DOID optic neuritis
disease MESH transverse myelitis
disease MESH neuropathic pain
disease MESH Cancer
disease DOID Cancer
disease MESH Syndromes
gene UNIPROT DESI1
gene UNIPROT SLC35G1
drug DRUGBANK Endothelin-1
gene UNIPROT EDN1
disease MESH Visual
gene UNIPROT CSF2
drug DRUGBANK Bosentan
disease MESH glioma
pathway BSID Glioma
drug DRUGBANK Rituximab
disease MESH neuromyelitis optica spectrum disorders
gene UNIPROT MARCO
drug DRUGBANK Resiniferatoxin
disease MESH anaplastic astrocytoma
disease DOID anaplastic astrocytoma
disease MESH optic neuropathy
disease DOID optic neuropathy
gene UNIPROT MOG
gene UNIPROT CYREN

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