Study Examines Levels of Trace Metals in Blood of Huntington’s Patients

Study Examines Levels of Trace Metals in Blood of Huntington’s Patients

Publication date: Oct 08, 2019

This post was originally published on this site Levels of certain trace metals are altered in the blood of people with Huntington’s disease, a new study found, suggesting that measuring and/or targeting these metals may be useful for studying, or perhaps treating, Huntington’s. Because of the effect trace metals can have on protein folding, researchers behind the new report wondered whether levels of any of these metals would be different in people with or without Huntington’s disease. Four of the essential trace metals were present at significantly higher levels in blood from people with Huntington’s than without; these were chromium (26 vs. 19 μg/L), iron (534,616 vs. 452,556 μg/L), selenium (138 vs. 101 μg/L) and zinc (5668 vs. 4640 μg/L). -We found abnormal concentrations of several metals in the blood of HD [Huntington’s disease] patients and propose that the metal profile may represent a useful tool for further insights of the pathology,” the researchers summarized, adding, -One therapeutic approach against HD or other neurodegenerative diseases could be targeting metals found in abnormal concentrations, since agents that target these metals may slow down or potentially reverse the course of the disease. ” The post Study Examines Levels of Trace Metals in Blood of Huntington’s Patients appeared first on Huntington’s Disease News.

Concepts Keywords
Amyotrophic Lateral Sclerosis Metal profile
Antimony Neurological disorders
Arsenic Differences impactful disease
Blood Reverse disease
Brain Amyotrophic lateral sclerosis
Cadmium Physical sciences
Chromium Chemistry
Cobalt Natural sciences
Copper Chemical elements
Huntingtin Dietary minerals
Huntington Native element minerals
Iron Post-transition metals
Manganese Trace metal
Misfolding Chromium
Molybdenum
Neurodegenerative Diseases
Neurological Disorders
Nickel
Parkinson
Pathology
Selenium
Tin
Vanadium
Zinc

Semantics

Type Source Name
gene UNIPROT DESI1
gene UNIPROT SLC35G1
drug DRUGBANK Zinc
drug DRUGBANK Copper
gene UNIPROT HTT
pathway BSID Protein folding
drug DRUGBANK Aspartame
drug DRUGBANK Chromium
drug DRUGBANK Cobalt
drug DRUGBANK Iron
drug DRUGBANK Manganese
drug DRUGBANK Molybdenum
drug DRUGBANK Selenium
drug DRUGBANK Vanadium
drug DRUGBANK Antimony
drug DRUGBANK Cadmium
disease MESH neurological disorders
disease MESH amyotrophic lateral sclerosis
disease DOID amyotrophic lateral sclerosis
disease MESH neurodegenerative diseases
pathway BSID Neurodegenerative Diseases

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *