Targeting Toxic T Helper Cells – Those with CXCR6 Receptor – Seen to Prevent MS in Mouse Model

Targeting Toxic T Helper Cells – Those with CXCR6 Receptor – Seen to Prevent MS in Mouse Model

Publication date: Oct 08, 2019

Targeting the chemokine receptor CXCR6, a protein at the surface of a certain group of T helper cells, prevented the development of multiple sclerosis (MS) in a mouse model of the disease, a study reports. Immune CD4 positive T-cells, known as T helper cells, play an important role in the autoimmune reaction against myelin (the protective coat surrounding neurons), the hallmark of MS. These cells are characterized by high levels of two pro-inflammatory molecules, called IL1β and IL-23, that help to sustain the immune reaction. By using an antibody against CXCR6, the researchers were able to replicate their previous results, those showing that depleting Sb1-expressing T-cells halted the development of MS. -We’ve demonstrated in mice you can target these cells and get rid of them,” Eileen Remold-O’Donnell, PhD, of the Program in Cellular and Molecular Medicine at Boston Children’s Hospital, and the study’s senior author, said in a press release. They observed that samples of synovial fluid (joint liquid) from patients with inflammatory autoimmune arthritis had high levels of CXCR6-positive T helper cells, whereas peripheral blood samples had not. These findings -suggest that therapies to regulate Sb1 levels or, more realistically, strategies to deplete CXCR6-marked TH [T helper] cells hold promise for mitigating autoimmune disorders such as MS,” the study concluded.

Concepts Keywords
Antibodies Sclerosis MS disease
Antibody Arthritis
Arthritis CXCR6 relevant disease
Autoimmune Inflammatory autoimmune diseases
Autoimmune Diseases Immunosuppression
Autoimmune Disorders Medical specialties
Autoimmune Reaction Immunology
Blood Branches of biology
Boston Medicine
CD4 Chemokine receptors
Chemokine Receptor Immune system
Childrens Hospital T cells
Cytotoxic CXCR6
Edelweiss CXC chemokine receptors
Genetic Screening T helper cell
Glucocorticoids IL17A
IL17a Autoimmunity
Immune Cells Antibodies
Immune Reaction
Immune System
Immunosuppression
Immunosuppressive Agents
Multiple Sclerosis
Myelin
Neurons
Patent
Pathogenic
PhD
PNAS
Receptor
Spinal Cord
Suicide
Synovial Fluid
T Cells

Semantics

Type Source Name
gene UNIPROT CXCR6
disease MESH development
disease MESH multiple sclerosis
disease DOID multiple sclerosis
pathway BSID Immune System
gene UNIPROT CD4
gene UNIPROT SERPINB1
gene UNIPROT SHKBP1
disease MESH suicide
disease MESH experimental autoimmune encephalomyelitis
gene UNIPROT IL17A
gene UNIPROT PDC
pathway BSID Release
disease MESH autoimmune diseases
disease MESH arthritis
disease DOID arthritis
drug DRUGBANK Tropicamide

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