Blocking LRP1 May Halt Inflammation, Promote Remyelination, Mouse Study Suggests

Blocking LRP1 May Halt Inflammation, Promote Remyelination, Mouse Study Suggests

Publication date: Oct 10, 2019

Blocking production of the low-density lipoprotein receptor-related protein 1 (LRP1) – involved in inflammatory and immune responses – specifically in myelin repair cells halts neuroinflammation and promotes myelin repair, a preclinical study shows. Researchers found that in an MS environment, OPCs acted like some immune cells, -ingesting” myelin molecules and presenting them to a specific type of immune T-cell known as CD8+ cells to induce immune reactions against them – a process called antigen presentation. Researchers at University of Virginia School of Medicine (UVA) now have discovered that OPCs’ antigen presentation -behavior” in MS is dependent of LRP1, a protein located in their cell membrane. First, the team confirmed the presence of LRP1 in OPCs in healthy human and mouse brains, and in two mouse models of MS associated with extensive myelin loss and induction of immune responses – the experimental autoimmune encephalomyelitis (EAE) model, and the cuprizone model (in which myelin loss is induced by the toxic agent cuprizone). The team proposed that the process of antigen -digestion” (including of myelin in MS) in OPCs is dependent of LRP1, and that these antigens are presented to CD8+ cells during myelin loss in MS, promoting further immune attacks against them.

Concepts Keywords
Alban Inflammatory response
Antigen Cells inflammation
Antigen Presentation MS
Antigens Medical specialties
Brain Branches of biology
CD8 Organ systems
Digestion Glial cells
Genetic Deletion Neurology
Glia Immunology
Hijacks Myelin
Immune Cells Neuroinflammation
Immune System LRP1
Immunology Remyelination
Inflammation Oligodendrocyte
Inflammatory Response Neuroscience
Intracellular
Lesion
Lipoprotein
Membrane
Mice
Molecule
Multiple Sclerosis
Myelin
Myelin Sheath
Nerve
Nerve Cells
Neuroprotection
Neuroscience
Oligodendrocyte
PhD
Receptor
T Cell
UVA
Virginia

Semantics

Type Source Name
gene UNIPROT ACTA1
gene UNIPROT MAGEE1
gene UNIPROT TNFSF14
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT LDLR
disease MESH Inflammation
gene UNIPROT LRP1
pathway BSID Immune System
drug DRUGBANK Tropicamide
gene UNIPROT PDC
pathway BSID Release
gene UNIPROT ANXA13

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