Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson’s Disease

Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson’s Disease

Publication date: Oct 10, 2019

Parkinson’s disease (PD) is a difficult to treat condition that impairs mobility and thinking. It is not fully treated by drugs and surgery. Two priority issues for most people with PD are “OFF-time” and Cognitive impairment. Even under best medical management, 74% of people with PD experience “OFF-time,” which is when medications are just not working right. OFF-time severely impacts both quality of life and thinking. Cognitive problems are found even in newly diagnosed people with PD and are very difficult to treat. However, the investigators’ research has shown that partnered dance-aerobic exercise (PDAE) reduces OFF-time on the official test for OFF-time of the Movement Disorders Society, the Movement Disorders Society Unified Parkinson Disease Rating Scale-IV, (MDS-UPDRS-IV). PDAE improves other symptoms too. Benefits of the therapy have lasted for at least one-month after PDAE sessions stopped. PDAE provides aerobic exercise during an improvisational, cognitively-engaging physical activity. Cognitive engagement is a critical component of PDAE. Previous research showed PDAE improved spatial cognition, the ability to navigate, to mentally picture shapes and paths in the mind and to know the relationships between objects, people and places. Also, the investigators showed with imaging of the brain using a magnet in a scanner that twice weekly PDAE training increases activity in brain regions used in thinking and decision making. The investigators know that exercise benefits mobility and cognitive problems. The investigators even think exercise might protect brain cells in people with PD. But no one has really been able to show with biomarkers that exercise is protective of brain cells in humans.

Concepts Keywords
Aerobic Exercise Imaging
Alcohol Untreated Major Depression
Angina G renal failure
Antiparkinsonian Brain death
Antipsychotics Severe cardiac disease
Aortic Stenosis Rigidity bradykinesia tremor
Assistive Device Classes Alcohol abuse
Beta Blockers Hemodialysis
Biomarkers Surgery
Bradykinesia RTT
Brain Psychiatric diagnosis
Brain Death Exercise physiology
Brain Scan Psychiatry
Cardiac Arrest Aging-associated diseases
Cardiac Defibrillator Cognitive disorders
Cardiac Disease Branches of biology
Claustrophobia Aerobic exercise
Cognition Human brain
Cognitive Stroke
Cognitive Impairment Dementia
Coin Flip MRI
Coin Toss
Congestive Heart Failure
Dance
Group H
Heart Rate
Hemodialysis
Hormones
KHz
Magnet
Memory
Movement Disorders
MRI
Parkinson
Physical Activity
Psychiatric Illness
Renal Failure
Resting Heart Rate
Stroke
Traumatic Brain Injury
Tremor
Wk

Semantics

Type Source Name
gene UNIPROT FBLN5
disease MESH Cognitive impairment
disease MESH Movement Disorders
disease MESH Parkinson Disease
disease DOID Parkinson Disease
disease DOID MDS
gene UNIPROT PAFAH1B1
gene UNIPROT TBATA
gene UNIPROT RENBP
gene UNIPROT DOCK3
drug DRUGBANK Tropicamide
disease MESH bradykinesia
disease MESH tremor
disease MESH Depression
disease MESH stroke
disease DOID stroke
disease MESH Alcohol abuse
disease DOID Alcohol abuse
disease MESH cardiac disease
disease MESH congestive heart failure
disease DOID congestive heart failure
disease MESH aortic stenosis
disease DOID aortic stenosis
disease MESH cardiac arrest
disease DOID cardiac arrest
disease MESH renal failure
disease DOID renal failure
drug DRUGBANK Ethanol
disease MESH contraindications
gene UNIPROT CYREN
disease MESH claustrophobia
gene UNIPROT NR4A2
gene UNIPROT ALG3
disease MESH Development

Original Article

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