Tissue Harvesting for Adoptive Tumor Infiltrating Lymphocyte Therapy in Metastatic Melanoma.

Tissue Harvesting for Adoptive Tumor Infiltrating Lymphocyte Therapy in Metastatic Melanoma.

Publication date: Sep 01, 2019

Adoptive transfer of tumor-infiltrating lymphocytes (TILs) combined with non-myeloablative chemotherapy (NMA) has been shown to prolong survival in patients with metastatic disease.

Tissue harvesting was performed form a variety of sites. TILs were isolated, expanded and infused with bolus high-dose IL-2.

Between 2008 and 2018, 242 lesions were resected for TILs harvesting from a range of sites form 196 patients without mortality and with minimal morbidity. Of those harvested, 75 were unable to complete therapy because of clinical deterioration during the wait period. Of 121 evaluable treated patients, there was no effect of metastatic site biopsied on the mean fold TIL expansion. Those receiving prior ipilimumab had a higher TIL fold expansion but a lower TIL fold expansion than those exposed to anti-PD1 therapy.

Harvesting may be safely performed with successful TIL expansion from most sites. Prior check point inhibitory immunotherapy may potentially influence TIL fold expansion.

Zippel, D., Friedman-Eldar, O., Rayman, S., Hazzan, D., Nissan, A., Schtrechman, G., Markel, G., Schachter, J., Itzhaki, O., and Besser, M.J. Tissue Harvesting for Adoptive Tumor Infiltrating Lymphocyte Therapy in Metastatic Melanoma. 24411. 2019 Anticancer Res (39):9.

Concepts Keywords
Biopsied Death Receptor tumor
Bolus Antibody therapy
Chemotherapy Adoptive transfer
Immunotherapy Chemotherapy
Ipilimumab Immunotherapy
Lymphocyte Medicine
Lymphocytes Clinical medicine
Melanoma Medical specialties
Metastatic Oncology
Morbidity Cancer treatments
Mortality Lymphocytes
Tumor Tumor-infiltrating lymphocytes
Immune system
Melanoma
Ipilimumab
Immunotherapy
TILS
Chemotherapy

Semantics

Type Source Name
pathway BSID Programmed Cell Death
gene UNIPROT RPL17
disease DOID Neoplasm
disease MESH Neoplasm Metastasis
gene UNIPROT PDCD1
gene UNIPROT SPATA2
drug DRUGBANK Ipilimumab
gene UNIPROT TLR1
gene UNIPROT IL2
gene UNIPROT BAMBI
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
disease MESH Tumor

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