Publication date: Oct 24, 2019
Deep brain stimulation (DBS) is an invasive therapy for patients with severe movement disorders aiming to retune abnormal brain network activity by local high frequency stimulation of the basal ganglia.
We acquired resting-state functional MRI in 20 patients with Parkinson’s disease with subthalamic DBS switched on and off.
Local impact of DBS on the motor subthalamic nucleus explained half the variance in global connectivity increases within the motor network (R = 0. 711, P
Moreover, local impact of DBS on the motor subthalamic nucleus could explain the degree to how much voxel-wise average brain connectivity normalized towards healthy controls (R = 0. 713, P
Our results show that resting state functional MRI may be acquired in DBS on and off conditions on clinical MRI hardware and that data are useful to gain additional insight into how DBS modulates the functional connectome of the human brain.
We demonstrate that effective DBS increases overall connectivity in the motor network, normalizes the network profile towards healthy controls and specifically strengthens thalamo-cortical connectivity while reducing striatal control over basal ganglia and cerebellar structures.
One issue that has been neglected in prior studies is that slight changes of millimetres in lead placement may result in large differences in clinical improvement (Horn et al. , 2019) and similarly, slight differences in connectivity profiles of DBS electrodes may be used to predict clinical improvement across patients, cohorts and DBS centres (Horn et al. , 2017).
Thus, we argue that it is crucial to incorporate DBS lead placement into an analysis of how they impact distributed brain networks.
We characterized changes in average connectivity (i. e. centrality) of brain regions and laid special focus on network changes as a function of the degree of motor STN-DBS modulation.