Deep Brain Stimulation Induced Normalization of the Human Functional Connectome in Parkinson’s Disease

Deep Brain Stimulation Induced Normalization of the Human Functional Connectome in Parkinson’s Disease

Publication date: Oct 24, 2019

Deep brain stimulation (DBS) is an invasive therapy for patients with severe movement disorders aiming to retune abnormal brain network activity by local high frequency stimulation of the basal ganglia.

We acquired resting-state functional MRI in 20 patients with Parkinson’s disease with subthalamic DBS switched on and off.

Local impact of DBS on the motor subthalamic nucleus explained half the variance in global connectivity increases within the motor network (R = 0. 711, P

Moreover, local impact of DBS on the motor subthalamic nucleus could explain the degree to how much voxel-wise average brain connectivity normalized towards healthy controls (R = 0. 713, P

Our results show that resting state functional MRI may be acquired in DBS on and off conditions on clinical MRI hardware and that data are useful to gain additional insight into how DBS modulates the functional connectome of the human brain.

We demonstrate that effective DBS increases overall connectivity in the motor network, normalizes the network profile towards healthy controls and specifically strengthens thalamo-cortical connectivity while reducing striatal control over basal ganglia and cerebellar structures.

One issue that has been neglected in prior studies is that slight changes of millimetres in lead placement may result in large differences in clinical improvement (Horn et al. , 2019) and similarly, slight differences in connectivity profiles of DBS electrodes may be used to predict clinical improvement across patients, cohorts and DBS centres (Horn et al. , 2017).

Thus, we argue that it is crucial to incorporate DBS lead placement into an analysis of how they impact distributed brain networks.

We characterized changes in average connectivity (i. e. centrality) of brain regions and laid special focus on network changes as a function of the degree of motor STN-DBS modulation.

Concepts Keywords
Atlas Deep brain stimulation
Basal Resting state fMRI
Basal Ganglia Subthalamic nucleus
Blood Connectome
Brain Basal ganglia
Cerebellar Neurotechnology
Cerebellum Neuroimaging
Cognitive Cognitive neuroscience
Cohort Magnetic resonance imaging
Connectome Neuroscience
Cortical Branches of biology
Coupling Medicine
DBS Deep Brain Stimulation
Deep Brain Stimulation Modulations motor network
Electrode Connectivity motor network
Finite Element Brain networks
FMRI Motor network
Fox
Frequency
Functional Connectivity
Functional MRI
Graph
Ipsilateral
Litvak
Modulation
Modulations
Motor Cortex
Motor Cortices
Movement Disorders
MRI
Multispectral Image
Neuroimaging
Normalized
Pallidum
Paradigm Shift
Parkinson
Pipeline
Premotor Cortex
Putamen
Regressor
Striatal
Subthalamic Nucleus
Thalamus
Variance
Voxel

Semantics

Type Source Name
disease MESH movement disorders
gene UNIPROT CYREN
gene UNIPROT AGRP
gene UNIPROT IMPACT
gene UNIPROT EEF1A2
gene UNIPROT LARGE1
drug DRUGBANK Aspartame
drug DRUGBANK Tropicamide
gene UNIPROT REST
gene UNIPROT NR4A3

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