The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study.

The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study.

Publication date: Apr 04, 2019

Background: Transcranial direct current stimulation (tDCS) of the primary motor cortex of the lower limb has been exploited in the treatment of patients with stroke and spastic lower limb paresis. We examined this stimulation efficacy in the treatment of multiple sclerosis (MS)-related walking disability. Methods: In a single-center randomized double-blind clinical trial study, 13 patients with MS and walking disability and Expanded Disability Status Scale (EDSS) score of 3 to 6 were randomized to the real and sham stimulation groups. In the real tDCS stimulation, 7 patients received anodal 2.5 mA stimulation at 1 cm anterior to the C point for 30-minute daily sessions in 7 consecutive days. The other group received sham stimulation with the same protocol. The primary outcome of the trial was change in the Timed 25-Foot Walk (T25-FW) from before to after the stimulation. We also assessed the Multiple Sclerosis Walking Scale-12 (MSWS-12). We employed linear mixed effects model to examine the efficacy of tDCS stimulation on changing the outcomes. Results: On average, patients who received real tDCS stimulation walked faster after 7 sessions of stimulation [Estimate = -2.7, standard error (SE) = 1.3, P = 0.049], while walking speed of sham stimulation recipients did not change. For every session of stimulation, recipients of real tDCS stimulation spent 2.7 seconds less for walking the 25 feet. Real tDCS stimulation was not effective in improving MSWS-12 scores. Conclusion: tDCS stimulation of the lower limb motor cortex speeded up patients with MS in walking, but without improvement in patients’ mobility in daily activities.

Oveisgharan, S., Karimi, Z., Abdi, S., and Sikaroodi, H. The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study. 19355. 2019 Iran J Neurol (18):2.

Concepts Keywords
Anodal Sham stimulation protocol
Brain Disability multiple sclerosis
Clinical Trial MS
Disability Treatment stroke
Double Blind Branches of biology
FW Medicine
Iran Neurophysiology
Motor Cortex Neuroscience
Multiple Sclerosis Neurotechnology
Paresis Electrotherapy
Primary Motor Cortex Neurostimulation
Protocol Medical devices
Spastic Transcranial direct-current stimulation
Standard Error Brain stimulation
Stroke Sham stimulation protocol
TDCS

Semantics

Type Source Name
disease MESH multiple sclerosis
disease DOID multiple sclerosis
disease MESH stroke
disease DOID stroke
disease MESH spastic
disease MESH paresis
disease MESH Mobility Limitation

Original Article

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