Positron Emission Tomography in Pediatric Neurodegenerative Disorders.

Positron Emission Tomography in Pediatric Neurodegenerative Disorders.

Publication date: Nov 01, 2019

Application of molecular neuroimaging using positron emission tomographic techniques to assess pediatric neurodegenerative disorders has been limited, unlike in adults where positron emission tomography has contributed to clinical diagnosis, monitoring of neurodegenerative disease progression, and assessment of novel therapeutic approaches. Yet, there is a huge unexplored potential of molecular imaging to improve our understanding of the pathophysiology of neurodegenerative disorders in children and provide radiological biomarkers that can be applied clinically. The obstacles in performing PET scans on children include sedation, radiation exposure, and access but, as will be illustrated, these barriers can be easily overcome. This review summarizes findings from PET studies that have been performed over the past three decades on children with various neurodegenerative disorders, including the neuronal ceroid lipofuscinoses, juvenile Huntington disease, Wilson disease, Niemann-Pick disease type C, Dravet syndrome, dystonia, mitochondrial disorders, inborn errors of metabolism, lysosomal storage diseases, dysmyelinating disorders, Rett syndrome, neurotransmitter disorders, glucose transporter Glut 1 deficiency, and Lesch-Nyhan disease. Because positron emission tomographic scans have often been clinically useful and have contributed to the management of these disorders, we suggest that the time has come for glucose metabolism positron emission tomographic scans to be reimbursed by insurance carriers for children with neurodegenerative disorders, and not restricted only to epilepsy surgery evaluation.

Chugani, H.T. Positron Emission Tomography in Pediatric Neurodegenerative Disorders. 06747. 2019 Pediatr Neurol (100):

Concepts Keywords
Biomarkers Radiation
Dravet Syndrome Tomography
Dystonia Positron Corporation
Epilepsy Whole-body nuclear scanning
Glucose Biomarker
Glucose Transporter Molecular imaging
Huntington Neuroimaging
Insurance Medicinal radiochemistry
Lysosomal Storage Diseases Positron emission tomography
Metabolism Medical physics
Mitochondrial Disorders Antimatter
Molecular Imaging Branches of biology
Neurodegenerative Medicine
Neurodegenerative Disorders Medical imaging
Neuroimaging Surgery
Neuronal Ceroid Lipofuscinoses Radiation
Neurotransmitter Lysosomal storage diseases
Pathophysiology Neuronal ceroid lipofuscinoses
Pediatric Nyhan disease
PET Pathophysiology neurodegenerative disorders
PET Scans Pediatric neurodegenerative disorders
Positron Emission Management disorders
Positron Emission Tomography
Radiation Exposure
Rett Syndrome
Sedation
Tomographic

Semantics

Type Source Name
disease DOID epilepsy
disease MESH epilepsy
pathway BSID Glucose metabolism
drug DRUGBANK Dextrose unspecified form
disease DOID Rett syndrome
disease MESH Rett syndrome
disease MESH lysosomal storage diseases
disease DOID Wilson disease
disease MESH juvenile Huntington disease
disease MESH neuronal ceroid lipofuscinoses
gene UNIPROT EHD1
disease DOID neurodegenerative disease
disease MESH diagnosis
disease MESH Neurodegenerative Disorders
disease DOID inborn errors of metabolism
disease MESH inborn errors of metabolism
disease DOID Dravet syndrome
disease DOID Niemann-Pick disease
disease MESH Niemann-Pick disease

Original Article

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