Cortical Atrophy and Cognitive Decline Accelerated in Stable and Progressive Multiple Sclerosis

Cortical Atrophy and Cognitive Decline Accelerated in Stable and Progressive Multiple Sclerosis

Publication date: Nov 06, 2019

The researchers found cognitive decline shifted from worsening lesional pathology in stable relapsing-remitting MS (RRMS) to deep gray matter atrophy in converting RRMS and to accelerated cortical atrophy in progressive MS (PMS) only.

The Expanded Disability Status Scale was used to assess overall disability in patients with MS. There was no difference between patients with PMS and stable RRMS in terms of the annual rate of deep gray matter atrophy (-0. 82%/year vs -0. 71%/year, respectively; P =. 11).

Concepts Keywords
Atrophy Magnetic resonance imaging
Cognitive MS
Cortical Organ systems
Disability Medical specialties
Gray Matter Medicine
Lesion Multiple sclerosis
Magnetic Resonance Imaging Multiple sclerosis research
MRI MRI
Multiple Sclerosis Magnetic resonance imaging
Neurology
Pathology
Progressive
Prospective Cohort Study
Symptom
Year 0

Semantics

Type Source Name
gene UNIPROT MTR
gene UNIPROT CYREN
disease DOID relapsing-remitting MS
disease DOID Multiple Sclerosis
disease MESH Multiple Sclerosis
disease MESH Cognitive Decline
disease MESH Atrophy

Original Article

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