TOMM40 polymorphism is associated with resting-state functional MRI results in patients with Alzheimer’s disease.

TOMM40 polymorphism is associated with resting-state functional MRI results in patients with Alzheimer’s disease.

Publication date: Nov 06, 2019

Translocase of outer mitochondrial membrane 40 (TOMM40) encodes translocase of the outer mitochondrial membrane (TOM), which is associated with mitochondrial dysfunction in Alzheimer’s disease (AD). TOMM40 rs157581-G has been reported to increase susceptibility to AD. However, the effect of TOMM40 rs157581-G in resting-state functional MRI (rs-fMRI) on AD has not been studied. Therefore, we aimed to investigate the role of TOMM40 rs157581-G on rs-fMRI results in AD patients.

Twenty-four AD patients were divided into two groups based on TOMM40 rs157581-G status, and clinical and imaging data were compared between the groups.

TOMM40 rs157581-G carriers of AD showed decreased regional homogeneity in the left precuneus and decreased amplitude of low-frequency fluctuations in the bilateral temporal poles compared with noncarriers of AD. TOMM40 rs157581-G carriers of AD also showed increased functional connectivity between the right middle occipital gyrus and the left supramarginal gyrus and decreased connectivity between the left superior occipital gyrus and the right transverse temporal gyrus in comparison with TOMM40 rs157581-G noncarriers.

We analyzed rs-fMRI characteristics of TOMM40 rs157581-G carriers of AD for the first time, which suggest that TOMM40 rs157581-G plays a harmful role in AD patients.

Xiao, X., Wei, J., Zhang, W., Jiao, B., Liao, X., Pan, C., Liu, X., Yan, X., Tang, B., Zhang, Y., Wang, D., Xing, W., Liao, W., and Shen, L. TOMM40 polymorphism is associated with resting-state functional MRI results in patients with Alzheimer’s disease. 22830. 2019 Neuroreport (30):16.

Concepts Keywords
Alzheimer Status clinical imaging
Amplitude Brain
FMRI Cerebrum
Frequency Gyri
Functional Connectivity Mitochondrial proteins
Functional MRI TOMM40
Gyrus Translocase
Mitochondrial Neuroimaging
Occipital Precuneus
Outer Mitochondrial Membrane Resting state fMRI
Polymorphism Transverse temporal gyrus
Precuneus Occipital gyri
Temporal Poles TOMM20
MRI

Semantics

Type Source Name
gene UNIPROT TOMM40
gene UNIPROT CYREN

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